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List of epidemics and pandemics

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Summary

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Pandemics timeline death tolls as of 2023

This is a list of the largest known epidemics and pandemics caused by an infectious disease in humans. Widespread non-communicable diseases such as cardiovascular disease and cancer are not included. An epidemic is the rapid spread of disease to a large number of people in a given population within a short period of time; in meningococcal infections, an attack rate in excess of 15 cases per 100,000 people for two consecutive weeks is considered an epidemic. Due to the long time spans, the first plague pandemic (6th century – 8th century) and the second plague pandemic (14th century – early 19th century) are shown by individual outbreaks, such as the Plague of Justinian (first pandemic) and the Black Death (second pandemic).

Infectious diseases with high prevalence are listed separately (sometimes in addition to their epidemics), such as malaria, which may have killed 50–60 million people.

Major epidemics and pandemics

By death toll

Ongoing epidemics and pandemics are in bold face. For a given epidemic or pandemic, the average of its estimated death toll range is used for ranking. If the death toll averages of two or more epidemics or pandemics are equal, then the smaller the range, the higher the rank. For the historical records of major changes in the world population, see world population.

Rank	Epidemics/pandemics	Disease	Death toll	Percentage of population lost	Years	Location
1	Plague of Justinian	Bubonic plague	15–100 million	25–60% of European population	541–549	North Africa, Europe, and Western Asia
2	HIV/AIDS pandemic	HIV/AIDS	45 million ()	–	1981–present	Worldwide
3	Black Death	Bubonic plague	25–50 million	30–60% of European population	1346–1353	Europe, Asia, and North Africa
4	1918 "Spanish" influenza pandemic	Influenza A/H1N1	25–50 million	1–5.4% of global population	1918–1920	Worldwide
5	COVID-19 pandemic	COVID-19	7.13–38 million(as of 2026)	–	2019–present	Worldwide
6	Third plague pandemic	Bubonic plague	12–15 million	–	1855–1960	Worldwide
7	Cocoliztli epidemic of 1545–1548	Cocoliztli, caused by an unidentified pathogen	5–15 million	27–80% of Mexican population	1545–1548	Mexico
8	Antonine Plague	Smallpox or measles	5–10 million	25–33% of Roman population	165–180 (possibly up to 190)	Roman Empire
9	1520 Mexico smallpox epidemic	Smallpox	5–8 million	23–37% of Mexican population	1519–1520	Mexico
10	1957–1958 influenza pandemic	Influenza A/H2N2	1–4 million	–	1957–1958	Worldwide
11	Hong Kong flu	Influenza A/H3N2	1–4 million	–	1968–1969	Worldwide
12	1918–1922 Russia typhus epidemic	Typhus	2–3 million	1–1.6% of Russian population	1918–1922	Russia
13	Cocoliztli epidemic of 1576	Cocoliztli	2–2.5 million	50% of Mexican population	1576–1580	Mexico
14	1772–1773 Persian Plague	Bubonic plague	2 million	–	1772–1773	Persia
15	735–737 Japanese smallpox epidemic	Smallpox	2 million	33% of Japanese population	735–737	Japan
16	Naples Plague	Bubonic plague	1.25 million	–	1656–1658	Southern Italy
17	1889–1890 pandemic	author=Knowable Magazine Staff	title=Pandemics in recent history	url=https://knowablemagazine.org/article/health-disease/2020/pandemics-recent-history	journal=Knowable Magazine	date=July 16, 2020	doi=10.1146/knowable-071520-2	doi-access=free	access-date=June 29, 2021	archive-date=November 29, 2022	archive-url=https://web.archive.org/web/20221129190516/https://knowablemagazine.org/article/health-disease/2020/pandemics-recent-history	url-status=live	url-access=subscription }}	1 million	–	1889–1890	Worldwide
18	1629–1631 Italian plague	Bubonic plague	1 million	–	1629–1631	Italy
19	1846–1860 cholera pandemic	Cholera	1 million	–	1846–1860	Worldwide

Infectious diseases with high prevalence

There have been various major infectious diseases with high prevalence worldwide, but they are currently not listed in the above table as epidemics/pandemics due to the lack of definite data, such as time span and death toll.

Malaria has had multiple documented temporary epidemics in otherwise non-affected or low-prevalence areas. Malaria is commonly spread by mosquitoes. The vast majority of its deaths are due to its constant prevalence in affected areas.
Tuberculosis (TB) became epidemic in Europe in the 18th and 19th century, showing a seasonal pattern, and is still taking place globally. Its symptoms include coughing up blood. It can generally be treated with strong antibiotics; untreated TB can be fatal. An opportunistic infection, TB is the leading cause of death of those with HIV/AIDS, and is considered an AIDS-defining clinical condition. The association between HIV/AIDS and TB has been described as the "TB/HIV syndemic". According to the World Health Organization, approximately 10 million new TB infections occur every year, and 1.5 million people die from it each year – making it the world's top infectious killer (before COVID-19 pandemic). However, there is a lack of sources which describe major TB epidemics with definite time spans and death tolls.
Hepatitis B: According to the World Health Organization, there are about 296 million people living with chronic hepatitis B, with 1.5 million new infections each year. In 2019, hepatitis B caused about 820,000 deaths, mostly from cirrhosis and hepatocellular carcinoma (primary liver cancer). In many places of Asia and Africa, hepatitis B has become endemic. In addition, a person is sometimes infected with both hepatitis B virus (HBV) and HIV, and this population (about 2.7 million) accounts for about 1% of the total HBV infections.
Hepatitis C: According to the World Health Organization, there are approximately 58 million people with chronic hepatitis C, with about 1.5 million new infections occurring per year. In 2019, approximately 290,000 people died from the disease, mostly from cirrhosis and hepatocellular carcinoma (primary liver cancer). There have been many hepatitis C virus (HCV) epidemics in history.

Chronology

Pre-1500s

Event	Years	Location	Disease	Death toll (estimate)	Ref.
1350 BC plague of Megiddo	1350 BC (circa)	Megiddo, land of Canaan	Amarna letters EA 244, Biridiya, the mayor of Megiddo complains to Amenhotep III of his area being "consumed by death, plague and dust"	Unknown	url=https://web.archive.org/web/20230404041541/https://www.kchanson.com/ANCDOCS/meso/amarna244.html	date=2023-04-04 }}''.
Hittite Plague/"Hand of Nergal"	1330 BC (circa)	Near East, Hittite Empire, Alashiya, possibly Egypt	Unknown, possibly Tularemia. Mentioned in Amarna letter EA 35 as the "Hand of Nergal", cause of death of Šuppiluliuma I.	Unknown
Plague of Athens	430–426 BC	Greece, Libya, Egypt, Ethiopia	Unknown, possibly typhus, typhoid fever or viral hemorrhagic fever	75,000–100,000	{{Cite journal	last1=Papagrigorakis	first1=Manolis J.	last2=Yapijakis	first2=Christos	last3=Synodinos	first3=Philippos N.	last4=Baziotopoulou-Valavani	first4=Effie	year=2007
412 BC epidemic	412 BC	Greece (Northern Greece, Roman Republic)	Unknown, possibly influenza	473,000 (10% of the Roman Population)
Antonine Plague	165–180 (possibly up to 190)	Roman Empire	Unknown, possibly smallpox	5–10 million
Jian'an Plague	217	Han dynasty	Unknown, possibly typhoid fever or viral hemorrhagic fever	2 million
Plague of Cyprian	249–262	Europe	Unknown, possibly smallpox or viral hemorrhagic fever	310,000
Plague of Justinian (beginning of first plague pandemic)	541–549	Europe and West Asia	Bubonic plague	15–100 million	last1=Mordechai	first1=Lee	last2=Eisenberg	first2=Merle	last3=Newfield	first3=Timothy P.	last4=Izdebski	first4=Adam	last5=Kay	first5=Janet E.	last6=Poinar	first6=Hendrik	date=2019-12-17	title=The Justinianic Plague: An inconsequential pandemic?	journal=Proceedings of the National Academy of Sciences	language=en	volume=116	issue=51	pages=25546–25554	doi=10.1073/pnas.1903797116	issn=0027-8424	pmid=31792176	pmc=6926030	bibcode=2019PNAS..11625546M	doi-access=free}}
580 Dysentery Epidemic in Gaul	580	Gaul	Dysentery or possibly smallpox	450,000 (10% of the Gaul population)
Roman Plague of 590 (part of first plague pandemic)	590	Rome, Byzantine Empire	Bubonic plague	Unknown
Plague of Sheroe (part of first plague pandemic)	627–628	Bilad al-Sham	Bubonic plague	25,000+
Plague of Amwas (part of first plague pandemic)	638–639	Byzantine Empire, West Asia, Africa	Bubonic plague	25,000+	last=Turner	first=David	date=November 1990	title=The Politics of Despair: The Plague of 746–747 and Iconoclasm in the Byzantine Empire1	journal=Annual of the British School at Athens	language=en	volume=85	pages=419–434	doi=10.1017/S006824540001577X	s2cid=153709117	issn=2045-2403}}
Plague of 664 (part of first plague pandemic)	664–689	British Isles	Bubonic plague	Unknown	last=Maddicott	first=J. R.	date=1 August 1997	title=Plague in seventh century England	url=https://academic.oup.com/past/article/156/1/7/1438455	journal=Past & Present	language=en	issue=156	pages=7–54	doi=10.1093/past/156.1.7	issn=0031-2746	access-date=12 February 2020	archive-date=8 March 2021	archive-url=https://web.archive.org/web/20210308075049/https://academic.oup.com/past/article/156/1/7/1438455	url-status=live	url-access=subscription}}
Plague of 698–701 (part of first plague pandemic)	698–701	Byzantine Empire, West Asia, Syria, Mesopotamia	Bubonic plague	Unknown	title=Plague and the end of Antiquity	editor-last=Little	editor-first=Lester K.	publisher=Cambridge University Press	year=2007	isbn=978-0-521-84639-4	location=Cambridge	page=104}}
735–737 Japanese smallpox epidemic	735–737	Japan	Smallpox	2 million (approx. of Japanese population)	last=Suzuki	first=A.	year=2011	title=Smallpox and the epidemiological heritage of modern Japan: Towards a total history	journal=Medical History	volume=55	issue=3	pages=313–318	doi=10.1017/S0025727300005329	pmc=3143877	pmid=21792253}}
Plague of 746–747 (part of first plague pandemic)	746–747	Byzantine Empire, West Asia, Africa	Bubonic plague	Unknown
Black Death (start of the second plague pandemic)	1346–1353	Eurasia and North Africa	Bubonic plague	75–200 million (30–60% of European population and 33% percent of the Middle Eastern population)
Sweating sickness (multiple outbreaks)	1485–1551	Britain (England) and later continental Europe	Unknown, possibly an unknown species of hantavirus	10,000+
1489 Spain typhus epidemic	1489	Spain	Typhus	17,000	title=Typhus, War, and Vaccines	url=http://www.historyofvaccines.org/content/blog/typhus-war-and-vaccines	website=historyofvaccines.org	date=16 March 2016	access-date=12 May 2020	archive-date=11 November 2020	archive-url=https://web.archive.org/web/20201111210627/https://www.historyofvaccines.org/content/blog/typhus-war-and-vaccines	url-status=dead}}

1500s

Event	Years	Location	Disease	Death toll (estimate)	Ref.
1510 influenza pandemic	1510	Asia, North Africa, Europe	Influenza	Unknown, around 1% of those infected
1520 Mexico smallpox epidemic	1519–1520	Mexico	Smallpox	5–8 million (40% of population)	title=Megadrought and Megadeath in 16th Century Mexico	date=April 8, 2002	pmc = 2730237	last1 = Acuna-Soto	first1 = R.	last2 = Stahle	first2 = D. W.	last3 = Cleaveland	first3 = M. K.	last4 = Therrell	first4 = M. D.	journal = Emerging Infectious Diseases	volume = 8	issue = 4	pages = 360–362	doi = 10.3201/eid0804.010175	pmid = 11971767}}
Cocoliztli epidemic of 1545–1548	1545–1548	Mexico	Possibly Salmonella enterica	5–15 million (80% of population)	url=https://www.newscientist.com/article/dn268-american-plague/	title=American plague	date=December 19, 2000	website=New Scientist	access-date=October 17, 2018	archive-url=https://web.archive.org/web/20181017163205/https://www.newscientist.com/article/dn268-american-plague/	archive-date=October 17, 2018	url-status=live}}
1557 influenza pandemic	1557–1559	Asia, Africa, Europe, and Americas	Influenza	Unknown (10% of the infected)
1561 Chile smallpox epidemic	1561–1562	Chile	Smallpox	120,000–150,000 (20–25% of native population)
1563 London plague (part of the second plague pandemic)	1563–1564	London, England	Bubonic plague	20,100+
Cocoliztli epidemic of 1576	1576–1580	Mexico	Possibly Salmonella enterica	2–2.5 million (50% of population)
1582 Tenerife plague epidemic (part of the second plague pandemic)	1582–1583	Tenerife, Spain	Bubonic plague	5,000–9,000
1592–1596 Seneca nation measles epidemic	1592–1596	Seneca nation, North America	Measles	Unknown
1592–1593 Malta plague epidemic (part of the second plague pandemic)	1592–1593	Malta	Bubonic plague	3,000
1592–1593 London plague (part of the second plague pandemic)	1592–1593	London, England	Bubonic plague	19,900+
1596–1602 Spain plague epidemic (part of the second plague pandemic)	1596–1602	Spain	Bubonic plague	600,000–700,000

1600s

Event	Years	Location	Disease	Death toll (estimate)	Ref.
1600–1650 South America malaria epidemic	1600–1650	South America	Malaria	Unknown
1603 London plague (part of the second plague pandemic)	1603	London, England	Bubonic plague	40,000
1616 New England infections epidemic	1616–1620	Southern New England, British North America, especially the Wampanoag people	Unknown, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D	1,143–3,429 (estimated 30–90% of population)
1629–1631 Italian plague (part of the second plague pandemic)	1629–1631	Italy	Bubonic plague	1 million	url=https://archive.org/details/epidemicspandemi0000hays	title=Epidemics and pandemics their impacts on human history	last=Hays	first=J. N.	date=2005	publisher=ABC-CLIO	isbn=978-1851096589	location=Santa Barbara, CA	page=103	url-access=registration}}
1632–1635 Augsburg plague epidemic (part of the second plague pandemic)	1632–1635	Augsburg, Germany	Bubonic plague	13,712
Massachusetts smallpox epidemic	1633–1634	Massachusetts Bay Colony, Thirteen Colonies	Smallpox	1,000
1634–1640 Wyandot people epidemic	1634–1640	Wyandot people, North America	Smallpox and Influenza	15,000–25,000
1637 London plague epidemic (part of the second plague pandemic)	1636–1637	London and Westminster, England	Bubonic plague	10,400
Great Plague in the late Ming dynasty (part of the second plague pandemic)	1633–1644	China	Bubonic plague	200,000+	last=Ch'iu	first=Chung-lin	date=	title=The Epidemics in Ming Beijing and the Responses from the Empire's Public Health System	url=http://www.ihp.sinica.edu.tw/~bihp/75/75.2/chiu.htm	journal=中央研究院歷史語言研究所集刊	language=zh	volume=	pages=331–388	via=	access-date=2021-01-18	archive-date=2021-01-02	archive-url=https://web.archive.org/web/20210102130336/http://www.ihp.sinica.edu.tw/~bihp/75/75.2/chiu.htm	url-status=live}}
Great Plague of Seville (part of the second plague pandemic)	1647–1652	Spain	Bubonic plague	500,000
1648 Central America yellow fever epidemic	1648	Central America	Yellow fever	Unknown
Naples Plague (part of the second plague pandemic)	1656–1658	Italy	Bubonic plague	1,250,000
1663–1664 Amsterdam plague epidemic (part of the second plague pandemic)	1663–1664	Amsterdam, Netherlands	Bubonic plague	24,148
Great Plague of London (part of the second plague pandemic)	1665–1666	England	Bubonic plague	100,000
1668 France plague (part of the second plague pandemic)	1668	France	Bubonic plague	40,000
1675–1676 Malta plague epidemic (part of the second plague pandemic)	1675–1676	Malta	Bubonic plague	11,300
1676–1685 Spain plague (part of the second plague pandemic)	1676–1685	Spain	Bubonic plague	Unknown
1677–1678 Boston smallpox epidemic	1677–1678	Massachusetts Bay Colony, British North America	Smallpox	750–1,000
Great Plague of Vienna (part of the second plague pandemic)	1679	Vienna, Austria	Bubonic plague	76,000	wstitle=Plague	volume=21	page=696	first=Joseph Frank	last=Payne}}
1681 Prague plague epidemic (part of the second plague pandemic)	1681	Prague, Czech Kingdom	Bubonic plague	83,000
1687 South Africa influenza outbreak	1687	South Africa	Unknown, possibly influenza	Unknown
1693 Boston yellow fever epidemic	1693	Boston, Massachusetts Bay Colony, British North America	Yellow fever	3,100+
1699 Charleston and Philadelphia yellow fever epidemic	1699	Charleston and Philadelphia, British North America	Yellow fever	520 (300 in Charleston, 220 in Philadelphia)

1700s

Event	Years	Location	Disease	Death toll (estimate)	Ref.
1702 New York City yellow fever epidemic	1702	New York City, British North America	Yellow fever	500
1702–1703 St. Lawrence Valley smallpox epidemic	1702–1703	New France, Canada	Smallpox	1,300
1707–1708 Iceland smallpox epidemic	1707–1709	Iceland	Smallpox	18,000+ (36% of population)	url=https://archive.org/details/epidemicspandemi0000hays	title=Epidemics and pandemics: their impacts on human history	last=J. N. Hays	publisher=ABC-CLIO	year=2005	isbn=978-1-85109-658-9	access-date=29 March 2011	url-access=registration	page=131}}
Great Northern War plague outbreak (part of the second plague pandemic)	1710–1712	Denmark, Sweden, Lithuania	Bubonic plague	164,000
1713–1715 North America measles epidemic	1713–1715	Thirteen Colonies and New France, Canada	Measles	Unknown
Great Plague of Marseille (part of the second plague pandemic)	1720–1722	France	Bubonic plague	100,000+
1721 Boston smallpox outbreak	1721–1722	Massachusetts Bay Colony	Smallpox	844
1730 Cádiz yellow fever epidemic	1730	Cádiz, Spain	Yellow fever	2,200
1732–1733 Thirteen Colonies influenza epidemic	1732–1733	Thirteen Colonies	Influenza	Unknown	url=http://www.ambrosevideo.com/items.cfm?id=1071	title=Ambrosevideo.com	access-date=2011-03-27	archive-url=https://web.archive.org/web/20160417075306/http://www.ambrosevideo.com/items.cfm?id=1071	archive-date=2016-04-17	url-status=live}}
1733 New France smallpox epidemic	1733	New France, Canada	Smallpox	Unknown
1735–1741 diphtheria epidemic	1735–1741	New England, Province of New York, Province of New Jersey, British North America	Diphtheria	20,000
Great Plague of 1738 (part of the second plague pandemic)	1738	Balkans	Bubonic plague	50,000
1738–1739 North Carolina smallpox epidemic	1738–1739	Province of Carolina, Thirteen Colonies	Smallpox	7,700–11,700
1741 Cartagena yellow fever epidemic	1741	Cartagena, Colombia	Yellow fever	20,000	url=https://jdc.jefferson.edu/cgi/viewcontent.cgi?referer=https://www.ecosia.org/&httpsredir=1&article=1004&context=yellow_fever_symposium	title=The Early History of Yellow Fever	publisher=Thomas Jefferson University	page=3	website=jdc.jefferson.edu	date=September 2009	access-date=16 May 2020	archive-date=6 January 2024	archive-url=https://web.archive.org/web/20240106083407/https://jdc.jefferson.edu/cgi/viewcontent.cgi?referer=https://www.ecosia.org/&httpsredir=1&article=1004&context=yellow_fever_symposium	url-status=live}}
1743 Sicily plague epidemic (part of the second plague pandemic)	1743	Messina, Sicily, Italy	Bubonic plague	40,000–50,000
1759 North America measles outbreak	1759	North America	Measles	Unknown
1760 Charleston smallpox epidemic	1760	Charleston, British North America	Smallpox	730–940
1762 Havana yellow fever epidemic	1762	Havana, Cuba	Yellow fever	8,000
1763 Pittsburgh area smallpox outbreak	1763	North America, present-day Pittsburgh area	Smallpox	Unknown
1770–1772 Russian plague (part of the second plague pandemic)	1770–1772	Russia	Bubonic plague	50,000
1772 North America measles epidemic	1772	North America	Measles	1,080
1772–1773 Persian Plague (part of the second plague pandemic)	1772–1773	Persia	Bubonic plague	2 million	pmc=5037359	pmid=27457063	doi=10.4178/epih.e2016033	volume=38	title=Plague in Iran: its history and current status	year=2016	author1=Hashemi Shahraki A	author2=Carniel E	author3=Mostafavi E	journal=Epidemiol Health	article-number=e2016033}}
1775–1776 England influenza outbreak	1775–1776	England	Influenza	Unknown	last1=Prichard	first1=Augustin	last2=Fothergill	first2=John	year=1894	title=Influenza in 1775	url=https://zenodo.org/record/1663344	journal=The Lancet	volume=143	issue=3673	pages=175–176	doi=10.1016/S0140-6736(01)66026-4	access-date=2019-07-05	archive-url=https://web.archive.org/web/20200103214437/https://zenodo.org/record/1663344	archive-date=2020-01-03	url-status=live}}
1775–1782 North American smallpox epidemic	1775–1782	Native populations in what is now the Pacific Northwest of the United States	Smallpox	11,000+	url=https://web.archive.org/web/20080526181907/http://www.historylink.org/essays/output.cfm?file_id=5100	date=2008-05-26}}, 23 Jan 2003, HistoryLink.org, Online Encyclopedia of Washington State History, accessed 2 Jun 2008
1778 Spain dengue fever outbreak	1778	Spain	Dengue fever	Unknown
1782 Influenza pandemic	1782	Worldwide	Influenza	Unknown
1788 Pueblo Indians smallpox epidemic	1788	Pueblo Indians in northern New Spain (what is now the Southwestern United States)	Smallpox	Unknown
1789–1790 New South Wales smallpox epidemic	1789–1790	New South Wales, Australia	Smallpox	125,251–175,351 (50–70% of native population)
1793 Philadelphia yellow fever epidemic	1793	Philadelphia, United States	Yellow fever	5,000+

1800s

Event	Years	Location	Disease	Death toll (estimate)	Ref.
1800–1803 Spain yellow fever epidemic	1800–1803	Spain	Yellow fever	60,000+
1801 Ottoman Empire and Egypt bubonic plague epidemic	1801	Ottoman Empire, Egypt	Bubonic plague	Unknown	url=https://archive.org/details/b21912245	title=Hygiene & diseases of warm climates	last=Andrew Davidson	publisher=Pentland	year=1893	page=337	access-date=31 March 2011}}
1802–1803 Saint-Domingue yellow fever epidemic	1802–1803	Saint-Domingue	Yellow fever	29,000–55,000	url=http://s2.medicina.uady.mx/observatorio/docs/er/ac/RE2013_Ac_Marr.pdf	title=The 1802 Saint-Domingue Yellow Fever Epidemic and the Louisiana Purchase (page 78)	date=2013	access-date=12 May 2020	archive-url=https://web.archive.org/web/20160204181607/http://s2.medicina.uady.mx/observatorio/docs/er/ac/RE2013_Ac_Marr.pdf	archive-date=4 February 2016	url-status=dead}}
1812 Russia typhus epidemic	1812	Russia	Typhus	300,000
1812–1819 Ottoman plague epidemic (part of the second plague pandemic)	1812–1819	Ottoman Empire	Bubonic plague	300,000+
1813–1814 Malta plague epidemic (part of the second plague pandemic)	1813–1814	Malta	Bubonic plague	4,500
Caragea's plague (part of the second plague pandemic)	1813	Romania	Bubonic plague	60,000
1817–1819 Ireland typhus epidemic	1817–1819	Ireland	Typhus	65,000
First cholera pandemic	1817–1824	Asia, Europe	Cholera	100,000+	url=https://archive.org/details/epidemicspandemi0000hays	title=Epidemics and pandemics: their impacts on human history	last=J. N. Hays	publisher=ABC-CLIO	year=2005	isbn=978-1-85109-658-9	access-date=29 March 2011	url-access=registration	page=193}}
1820 Savannah yellow fever epidemic	1820	Savannah, Georgia, United States	Yellow fever	700
1821 Barcelona yellow fever epidemic	1821	Barcelona, Spain	Yellow fever	5,000–20,000	wstitle=Yellow Fever	volume=28	pages=910–911}}
Second cholera pandemic	1826–1837	Asia, Europe, North America	Cholera	100,000+	url=https://archive.org/details/epidemicspandemi0000hays	title=Epidemics and pandemics: their impacts on human history	last=J. N. Hays	publisher=ABC-CLIO	year=2005	isbn=978-1-85109-658-9	access-date=29 March 2011	url-access=registration	page=211}}
1828–1829 New South Wales smallpox epidemic	1828–1829	New South Wales, Australia	Smallpox	19,000
Groningen epidemic	1829	Netherlands	Malaria	2,800
1829–1833 Pacific Northwest malaria epidemic	1829–1833	Pacific Northwest, United States	Malaria, possibly other diseases too	150,000
1829–1835 Iran plague outbreak	1829–1835	Iran	Bubonic plague	Unknown
1834–1836 Egypt plague epidemic	1834–1836	Egypt	Bubonic plague	Unknown	url=https://web.archive.org/web/20081120024817/http://ark.cdlib.org/ark:/13030/ft5t1nb3mq/	date=2008-11-20}}, Berkeley: University of California Press, c1990.
1837 Great Plains smallpox epidemic	1837–1838	Great Plains, United States and Canada	Smallpox	17,000+
1841 Southern United States yellow fever epidemic	1841	Southern United States (especially Louisiana and Florida)	Yellow fever	3,498
1847 North American typhus epidemic	1847–1848	Canada	Typhus	20,000+	last=Gallagher	first=The Reverend John A.	year=1936	title=The Irish Emigration of 1847 and Its Canadian Consequences	url=http://www.umanitoba.ca/colleges/st_pauls/ccha/Back%20Issues/CCHA1935-36/Gallagher.html	journal=Canadian Catholic Historical Association Report, University of Manitoba Web Site	access-date=2008-03-23	archive-url=https://web.archive.org/web/20071011072535/http://umanitoba.ca/colleges/st_pauls/ccha/Back%20Issues/CCHA1935-36/Gallagher.html	archive-date=2007-10-11	url-status=live}}
1847 Southern United States yellow fever epidemic	1847	Southern United States (especially New Orleans)	Yellow fever	3,400
1847–1848 influenza epidemic	1847–1848	Worldwide	Influenza	Unknown	year=1849	title=On the Influenza, or Epidemic Catarrhal Fever of 1847–8	journal=The American Journal of the Medical Sciences	volume=18	issue=35	pages=148–154	doi=10.1097/00000441-184907000-00018	pmc=5277660	last1=a s	first1=&NA }}
1848–1849 Hawaii epidemic of infections	1848–1849	Hawaiian Kingdom	Measles, whooping cough, dysentery and influenza	10,000
1853 New Orleans yellow fever epidemic	1853	New Orleans, United States	Yellow fever	7,970
Third cholera pandemic	1846–1860	Worldwide	Cholera	1 million+	url=https://archive.org/details/epidemicspandemi0000hays	title=Epidemics and pandemics: their impacts on human history	last=J. N. Hays	publisher=ABC-CLIO	year=2005	isbn=978-1-85109-658-9	access-date=29 March 2011	url-access=registration	page=236}}
1853 Ottoman Empire plague epidemic	1853	Ottoman Empire	Bubonic plague	Unknown	last1=Anstie	first1=Francis Edmund	last2=Lawson	first2=Henry	url=https://books.google.com/books?id=cWUCAAAAYAAJ	title=Practitioner	year=1877	access-date=29 March 2011}}
1853 Copenhagen cholera outbreak	1853	Copenhagen, Denmark	Cholera	4,737
1854 Broad Street cholera outbreak	1854	London, England	Cholera	616	url=https://archive.org/details/b28985266	title=On the mode of communication of cholera	last=John Snow	publisher=John Churchill	year=1855	access-date=29 March 2011}}
1855 Norfolk yellow fever epidemic	1855	Norfolk and Portsmouth, England	Yellow fever	3,000 (2,000 in Norfolk, 1,000 in Portsmouth)
Third plague pandemic	1855–1960	Worldwide	Bubonic plague	12–15 million (India and China)
1855–1857 Montevideo yellow fever epidemic	1855–1857	Montevideo, Uruguay	Yellow fever	3,400 (first wave; 900, second wave; 2,500)
1857 Lisbon yellow fever epidemic	1857	Lisbon, Portugal	Yellow fever	6,000
1857 Victoria smallpox epidemic	1857	Victoria, Australia	Smallpox	Unknown
1857–1859 Europe and the Americas influenza epidemic	1857–1859	Europe, North America, South America	Influenza	Unknown
1862 Pacific Northwest smallpox epidemic	1862–1863	Pacific Northwest, Canada and United States	Smallpox	20,000+
1861–1865 United States typhoid fever epidemic	1861–1865	United States	Typhoid fever	80,000
Fourth cholera pandemic	1863–1875	Middle East	Cholera	600,000	url=https://archive.org/details/epidemicspandemi0000hays	title=Epidemics and pandemics: their impacts on human history	last=J. N. Hays	publisher=ABC-CLIO	year=2005	isbn=978-1-85109-658-9	access-date=29 March 2011	url-access=registration	page=267}}
1867 Sydney measles epidemic	1867	Sydney, Australia	Measles	748	url=https://dictionaryofsydney.org/entry/epidemics	title=Epidemics	website=dictionaryofsydney.org	date=2008	access-date=16 May 2020	archive-date=28 March 2020	archive-url=https://web.archive.org/web/20200328053832/https://dictionaryofsydney.org/entry/epidemics	url-status=live}}
1871 Buenos Aires yellow fever epidemic	1871	Buenos Aires, Argentina	Yellow fever	13,500–26,200
1870–1875 Europe smallpox epidemic	1870–1875	Europe	Smallpox	500,000
1875 Fiji measles outbreak	1875	Fiji	Measles	40,000
1875–1876 Australia scarlet fever epidemic	1875–1876	Australia	Scarlet fever	8,000
1876 Ottoman Empire plague epidemic	1876	Ottoman Empire	Bubonic plague	20,000
1878 New Orleans yellow fever epidemic	1878	New Orleans, United States	Yellow fever	4,046
1878 Mississippi Valley yellow fever epidemic	1878	Mississippi Valley, United States	Yellow fever	13,000
Fifth cholera pandemic	1881–1896	Asia, Africa, Europe, South America	Cholera	298,600	url=https://archive.org/details/epidemicspandemi0000hays	title=Epidemics and pandemics: their impacts on human history	last=J. N. Hays	publisher=ABC-CLIO	year=2005	isbn=978-1-85109-658-9	access-date=29 March 2011	url-access=registration	page=303}}
1885 Montreal smallpox epidemic	1885	Montreal, Canada	Smallpox	3,164
1889–1890 pandemic	1889–1890	Worldwide	Influenza or Human coronavirus OC43 / HCoV-OC43 (disputed)	1 million	url=https://archive.org/details/b21459393	title=Further report and papers on epidemic influenza, 1889–92: with an introduction by the medical officer of the Local Government Board	last=Great Britain. Local Government Board	publisher=Eyre	year=1893	page=49	access-date=29 March 2011}}
1894 Hong Kong plague (part of the third plague pandemic)	1894–1929	Hong Kong	Bubonic plague	20,000+
Bombay plague epidemic (part of the third plague pandemic)	1896–1905	Bombay, India	Bubonic plague	20,788
1896–1906 Congo Basin African trypanosomiasis epidemic	1896–1906	Congo Basin	African trypanosomiasis	500,000	url=https://www.who.int/trypanosomiasis_african/country/history/en/index5.html	archive-url=https://web.archive.org/web/20080323231311/http://www.who.int/trypanosomiasis_african/country/history/en/index5.html	url-status=dead	archive-date=March 23, 2008	title=The history of sleeping sickness	website=WHO	access-date=12 May 2020}}
1899 Porto plague outbreak (part of the third plague pandemic)	1899	Porto, Portugal	Bubonic plague	132	last=Pontes	first=David	date=2012	title=O cerco da peste no Porto: Cidade, imprensa e saúde pública na crise sanitária de 1899	type=master's degree	publisher=Faculdade de Letras da Universidade do Porto	url=https://repositorio-aberto.up.pt/bitstream/10216/73326/2/28279.pdf	language=pt	access-date=2 March 2020	archive-date=2 March 2020	archive-url=https://web.archive.org/web/20200302232248/https://repositorio-aberto.up.pt/bitstream/10216/73326/2/28279.pdf	url-status=live }}
Sixth cholera pandemic	1899–1923	Europe, Asia, Africa	Cholera	800,000+	url=https://archive.org/details/epidemicspandemi0000hays	title=Epidemics and pandemics: their impacts on human history	last=J. N. Hays	publisher=ABC-CLIO	year=2005	isbn=978-1-85109-658-9	access-date=29 March 2011	url-access=registration	page=345}}

1900s

Event	Years	Location	Disease	Death toll (estimate)	Ref.
San Francisco plague of 1900–1904 (part of the third plague pandemic)	1900–1904	San Francisco, United States	Bubonic plague	119
1900 Sydney bubonic plague epidemic (part of the third plague pandemic)	1900	Australia	Bubonic plague	103
1900–1920 Uganda African trypanosomiasis epidemic	1900–1920	Uganda	African trypanosomiasis	200,000–300,000
Papua New Guinea kuru epidemic	1901–2009	Papua New Guinea	Kuru	2,700–3,000+
1903 Fremantle plague epidemic (part of the third plague pandemic)	1903	Fremantle, Western Australia	Bubonic plague	4
1906 malaria outbreak in Ceylon	1906–1936	Ceylon	Malaria	80,000
Manchurian plague (part of the third plague pandemic)	1910–1911	China	Pneumonic plague	60,000	url=https://disasterhistory.org/the-manchurian-plague-1910-11	title=Manchurian plague, 1910–11	last=Meiklejohn	first=Iain	website=Disaster History	language=en-GB	access-date=23 April 2020	archive-date=8 March 2018	archive-url=https://web.archive.org/web/20180308205528/https://disasterhistory.org/the-manchurian-plague-1910-11	url-status=live}}
1916 United States polio epidemic	1916	United States	Poliomyelitis	7,130	url=https://ourworldindata.org/polio	title=Polio (graph "Reported paralytic polio cases and deaths in the United States since 1910")	last1=Ochman	first1=Sophie	last2=Roser	first2=Max	journal=Our World in Data	date=9 November 2017	publisher=OurWorldInData.org	access-date=15 May 2020	archive-date=28 March 2018	archive-url=https://web.archive.org/web/20180328105153/https://ourworldindata.org/polio	url-status=live}}
1918 influenza pandemic ('Spanish flu')	1918–1920	Worldwide		Influenza A virus subtype H1N1	17–100 million	last1=P. Spreeuwenberg	display-authors=etal	title=Reassessing the Global Mortality Burden of the 1918 Influenza Pandemic.	journal=American Journal of Epidemiology	volume=187	issue=12	pages=2561–2567	date=1 December 2018	doi=10.1093/aje/kwy191	pmid=30202996	pmc=7314216}}
1918–1922 Russia typhus epidemic	1918–1922	Russia	Typhus	2–3 million
1919–1930 encephalitis lethargica epidemic	1919–1930	Worldwide	Encephalitis lethargica	500,000	last1=Ravenholt	first1=R. T	last2=Foege	first2=WilliamH	title=1918 Influenza, Encephalitis Lethargica, Parkinsonism	date=1982-10-16	url=http://www.sciencedirect.com/science/article/pii/S0140673682908200	journal=The Lancet	series=Originally published as Volume 2, Issue 8303	language=en	volume=320	issue=8303	pages=860–864	doi=10.1016/S0140-6736(82)90820-0	pmid=6126720	s2cid=45138249	issn=0140-6736	access-date=2020-12-23	archive-date=2021-07-12	archive-url=https://web.archive.org/web/20210712225718/https://www.sciencedirect.com/science/article/abs/pii/S0140673682908200	url-status=live	url-access=subscription}}
Duwaimeh smallpox epidemic	1921–1922	Duwaimeh, Mandatory Palestine	Smallpox	16
1924 Los Angeles pneumonic plague outbreak	1924	Los Angeles, United States	Pneumonic plague	30
1924–1925 Minnesota smallpox epidemic	1924–1925	Minnesota, United States	Smallpox	500
1927 Montreal typhoid fever epidemic	1927	Montreal, Canada	Typhoid fever	538
1929–1930 psittacosis pandemic	1929–1930	Worldwide	Psittacosis	100+	last=Honigsbaum	first=Mark	url=https://openaccess.city.ac.uk/id/eprint/23272/1/The%20Pandemic%20Century-ver3.pdf	title=The Pandemic Century: One Hundred Years of Panic, Hysteria and Hubris	publisher=Hurst & Company	year=2020	isbn=9781787381216	location=London	pages=67–98	chapter=3. The Great Parrot Fever Pandemic	access-date=2020-06-27	archive-date=2021-07-12	archive-url=https://web.archive.org/web/20210712225713/https://openaccess.city.ac.uk/id/eprint/23272/1/The%20Pandemic%20Century-ver3.pdf	url-status=live}}
1937 Croydon typhoid outbreak	1937	Croydon, United Kingdom	Typhoid fever	43	last1=Ravenel	first1=Mazÿk P.	date=May 1938	title=The Croydon Epidemic of Typhoid Fever	journal=American Journal of Public Health and the Nation's Health	volume=28	issue=5	pages=644–646	doi=10.2105/AJPH.28.5.644	pmid=18014847	pmc=1529192	doi-access=free	author-link1=Mazÿck P. Ravenel}}
1937 Australia polio epidemic	1937	Australia	Poliomyelitis	Unknown
1938 South Africa bubonic plague	1938	South Africa	Bubonic plague	Unknown
1940 Sudan yellow fever epidemic	1940	Sudan	Yellow fever	1,627
1942–1944 Egypt malaria epidemic	1942–1944	Egypt	Malaria	Unknown	977-424-295-5}} pp. 4–6
1946 Egypt relapsing fever epidemic	1946	Egypt	Relapsing fever	Unknown
1947 Egypt cholera epidemic	1947	Egypt	Cholera	10,277	pmc=2553924	pmid=20603928	volume=1	title=Cholera Epidemic in Egypt (1947): A Preliminary Report	year=1948	author=Shousha AT	journal=Bull. World Health Organ.	issue = 2	pages=353–381}}
1948–1952 United States polio epidemic	1948–1952	United States	Poliomyelitis	9,000
1957–1958 influenza pandemic ('Asian flu')	1957–1958	Worldwide	Influenza A virus subtype H2N2	1–4 million	last=	first=	date=2013	title=Pandemic Influenza Risk Management WHO Interim Guidance	url=https://www.who.int/influenza/preparedness/pandemic/GIP_PandemicInfluenzaRiskManagementInterimGuidance_Jun2013.pdf?ua=1	url-status=live	archive-url=https://web.archive.org/web/20210121225326/https://www.who.int/influenza/preparedness/pandemic/GIP_PandemicInfluenzaRiskManagementInterimGuidance_Jun2013.pdf?ua=1	archive-date=2021-01-21	access-date=7 December 2020	website=World Health Organization	page=19}}
1960–1962 Ethiopia yellow fever epidemic	1960–1962	Ethiopia	Yellow fever	30,000
Hong Kong flu	1968–1970	Worldwide	Influenza A virus subtype H3N2	1–4 million	url=http://apps.who.int/gb/ebwha/pdf_files/WHA64/A64_10-en.pdf	title=Report of the Review Committee on the Functioning of the International Health Regulations (2005) in relation to Pandemic (H1N1) 2009	date=2011-05-05	page=37	url-status=live	archive-url=https://web.archive.org/web/20150514145306/http://apps.who.int/gb/ebwha/pdf_files/WHA64/A64_10-en.pdf	archive-date=14 May 2015	access-date=1 March 2015}}
1971 Staphorst polio epidemic	1971	Staphorst, Netherlands	Poliomyelitis	5
1972 Yugoslav smallpox outbreak	1972	Yugoslavia	Smallpox	35
London flu	1972–1973	United States	Influenza A virus subtype H3N2	1,027
1973 Italy cholera epidemic	1973	Italy	Cholera (El Tor strain)	24
1974 smallpox epidemic in India	1974	India	Smallpox	15,000	url=http://www.smallpoxhistory.ucl.ac.uk/	title=The control and eradication of smallpox in South Asia	website=www.smallpoxhistory.ucl.ac.uk	access-date=2008-12-18	url-status=dead	archive-url=https://web.archive.org/web/20081019023043/http://www.smallpoxhistory.ucl.ac.uk/	archive-date=2008-10-19}}
1977 Russian flu	1977–1979	Worldwide	Influenza A virus subtype H1N1	700,000	last1=Michaelis	first1=Martin	last2=Doerr	first2=Hans Wilhem	last3=Cinatl	first3=Jindrich	date=2009-08-01	title=Novel swine-origin influenza A virus in humans: another pandemic knocking at the door	journal=Medical Microbiology and Immunology	language=en	volume=198	issue=3	pages=175–183 (Table 1)	doi=10.1007/s00430-009-0118-5	pmid=19543913	s2cid=20496301	issn=1432-1831	doi-access=free}}
Sverdlovsk anthrax leak	1979	Russia	Anthrax	105
1984 Western Sahara plague	1984	Western Sahara	Bubonic plague	64
1986 Oju yellow fever epidemic	1986	Oju, Nigeria	Yellow fever	5,600+
1987 Mali yellow fever epidemic	1987	Mali	Yellow fever	145
1988 Shanghai hepatitis A epidemic	1988	Shanghai, China	Hepatitis A	31–47
1991 Bangladesh cholera epidemic	1991	Bangladesh	Cholera	8,410–9,432
1991 Latin America cholera epidemic	1991–1993	Peru, Chile, Bolivia, Ecuador, Colombia, Mexico, El Salvador, Guatemala	Cholera	8,000
1994 plague in India	1994	India	Bubonic plague and Pneumonic plague	56
United Kingdom BSE outbreak	1996–2001	United Kingdom	Variant Creutzfeldt–Jakob disease / vCJD	178
1996 West Africa meningitis epidemic	1996	West Africa	Meningitis	10,000
1998–1999 Malaysia Nipah virus outbreak	1998–1999	Malaysia	Nipah virus infection	105	url=http://www.mjpath.org.my/2007.2/02Nipah_Virus_lessons.pdf	title=Lessons from the Nipah virus outbreak in Malaysia	author1=Lai-Meng Looi	author2=Kaw-Bing Chua	publisher=Department of Pathology, University of Malaya and National Public Health Laboratory of the Ministry of Health, Malaysia	journal=The Malaysian Journal of Pathology	year=2007	volume=29	number=2	pages=63–67	pmid=19108397	archive-url=https://web.archive.org/web/20190830060915/http://www.mjpath.org.my/2007.2/02Nipah_Virus_lessons.pdf	archive-date=30 August 2019	url-status=live}}
1998–2000 Democratic Republic of the Congo Marburg virus outbreak	1998–2000	Democratic Republic of the Congo	Marburg virus	128	url=https://www.cdc.gov/vhf/marburg/resources/outbreak-table.html	title=Outbreak Table \| Marburg Hemorrhagic Fever \| CDC	access-date=2021-08-13	archive-date=2015-01-21	archive-url=https://web.archive.org/web/20150121181229/http://www.cdc.gov/vhf/marburg/resources/outbreak-table.html	url-status=live}}

2000s

Event	Years	Location	Disease	Death toll (estimate)	Ref.
2000 Central America dengue epidemic	2000	Central America	Dengue fever	40+
2001 Nigeria cholera epidemic	2001	Nigeria	Cholera	400+
2001 South Africa cholera epidemic	2001	South Africa	Cholera	139
2002–2004 SARS outbreak	2002–2004	Worldwide	Severe acute respiratory syndrome / SARS	774
2003–2019 Asia and Egypt avian influenza epidemic	2003–2019	China, Southeast Asia and Egypt	Influenza A virus subtype H5N1	455
2004 Indonesia dengue epidemic	2004	Indonesia	Dengue fever	658
2004 Sudan Ebola outbreak	2004	Sudan	Ebola	7
2004–2005 Angola Marburg virus outbreak	2004–2005	Angola	Marburg virus	227
2005 dengue outbreak in Singapore	2005	Singapore	Dengue fever	27
2006 Luanda cholera epidemic	2006	Luanda, Angola	Cholera	1,200+
2006 Ituri Province plague epidemic	2006	Ituri Province, Democratic Republic of the Congo	Bubonic plague	61
2006 India malaria outbreak	2006	India	Malaria	17
2006 dengue outbreak in India	2006	India	Dengue fever	50+
2006 dengue outbreak in Pakistan	2006	Pakistan	Dengue fever	50+
2006 Philippines dengue epidemic	2006	Philippines	Dengue fever	1,000
2006–2007 East Africa Rift Valley fever outbreak	2006–2007	East Africa	Rift Valley fever	394
Mweka Ebola epidemic	2007	Democratic Republic of the Congo	Ebola	187
2007 Ethiopia cholera epidemic	2007	Ethiopia	Cholera	684
2007 Iraq cholera outbreak	2007	Iraq	Cholera	10
2007 Puerto Rico, Dominican Republic, and Mexico dengue fever epidemic	2007	Puerto Rico, Dominican Republic, Mexico	Dengue fever	183
2007 Uganda Ebola outbreak	2007	Uganda	Ebola	37	title = Ebola virus disease	url = https://www.who.int/en/news-room/fact-sheets/detail/ebola-virus-disease	publisher = World Health Organization (WHO)	access-date = 26 February 2020	date = 12 February 2018	df = dmy-all	archive-date = 18 April 2018	archive-url = https://web.archive.org/web/20180418095601/http://www.who.int/mediacentre/factsheets/fs103/en/	url-status = live }}
2007 Netherlands Q-fever epidemic	2007–2018	Netherlands	Q-fever	95
2008 Brazil dengue epidemic	2008	Brazil	Dengue fever	67
2008 Cambodia dengue epidemic	2008	Cambodia	Dengue fever	407
2008 Chad cholera epidemic	2008	Chad	Cholera	123
2008–2017 China hand, foot, and mouth disease epidemic	2008–2017	China	Hand, foot, and mouth disease	3,322+	doi=10.3201/eid2403.171303	title=Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008–2015	year=2018	last1=Huang	first1=Jiao	last2=Liao	first2=Qiaohong	last3=Ooi	first3=Mong How	last4=Cowling	first4=Benjamin J.	last5=Chang	first5=Zhaorui	last6=Wu	first6=Peng	last7=Liu	first7=Fengfeng	last8=Li	first8=Yu	last9=Luo	first9=Li	last10=Yu	first10=Shuanbao	last11=Yu	first11=Hongjie	last12=Wei	first12=Sheng	journal=Emerging Infectious Diseases	volume=24	issue=3	pages=432–442	pmid=29460747	pmc=5823341}}2008–2015, ≈13 million HFMD cases were reported, including 123,261 severe cases and 3,322 deaths in 31 provinces of mainland China
2008 India cholera epidemic	2008	India	Cholera	115
2008 Madagascar plague outbreak	2008	Madagascar	Bubonic plague	18+
2008 Philippines dengue epidemic	2008	Philippines	Dengue fever	172
2008 Zimbabwean cholera outbreak	2008–2009	Zimbabwe	Cholera	4,293	url=https://www.who.int/cholera/countries/ZimbabweCountryProfileOct2009.pdf	access-date=16 February 2020	title=Cholera Country Profile: Zimbabwe	date=31 October 2009	publisher=World Health Organization – Global Task Force on Cholera Control	archive-date=31 October 2017	archive-url=https://web.archive.org/web/20171031123847/http://www.who.int/cholera/countries/ZimbabweCountryProfileOct2009.pdf	url-status=live }}
2009 Bolivian dengue fever epidemic	2009	Bolivia	Dengue fever	18
2009 Gujarat hepatitis outbreak	2009	India	Hepatitis B	49
Queensland 2009 dengue outbreak	2009	Queensland, Australia	Dengue fever	1+ (503 cases)
2009–2010 West African meningitis outbreak	2009–2010	West Africa	Meningitis	1,100
2009 swine flu pandemic	2009–2010	Worldwide	Influenza A virus subtype H1N1	Lab confirmed deaths: 18,449 (reported to the WHO)
Estimated death toll: 284,000 (possible range 151,700–575,400)
2010s Haiti cholera outbreak	2010–2019	Haiti	Cholera (strain serogroup O1, serotype Ogawa)	10,075
2010–2014 Democratic Republic of the Congo measles outbreak	2010–2014	Democratic Republic of the Congo	Measles	4,500+
2011 Vietnam hand, foot, and mouth disease epidemic	2011	Vietnam	Hand, foot, and mouth disease	170
2011 dengue outbreak in Pakistan	2011	Pakistan	Dengue fever	350+
2012 yellow fever outbreak in Darfur, Sudan	2012	Darfur, Sudan	Yellow fever	171
2013 dengue outbreak in Singapore	2013	Singapore	Dengue fever	8
2013 Vietnam measles outbreak	2013–2014	Vietnam	Measles	142
Western African Ebola virus epidemic	2013–2016	Worldwide, primarily concentrated in Guinea, Liberia, Sierra Leone		Ebola	11,323+
2013–2014 chikungunya outbreak	2013–2015	Americas	Chikungunya	183
2013–19 avian influenza epidemic	2013–2019	China	Influenza A virus subtype H7N9	616
21st century Madagascar plague outbreaks	2014–2017	Madagascar	Bubonic plague	292
Flint water crisis	2014–2015	Flint, Michigan, United States	Legionnaires' disease	12
2014 Odisha hepatitis outbreak	2014–2015	India	Primarily Hepatitis E, but also Hepatitis A	36	url=http://www.deccanherald.com/content/460129/odisha-grapples-jaundice-outbreak.html	title=Odisha grapples with jaundice outbreak	date=17 February 2015	work=Deccan Herald	access-date=17 February 2015	archive-url=https://web.archive.org/web/20150217120135/http://www.deccanherald.com/content/460129/odisha-grapples-jaundice-outbreak.html	archive-date=17 February 2015	url-status=live}}
2015 Indian swine flu outbreak	2015	India	Influenza A virus subtype H1N1	2,035	url=http://indianexpress.com/article/india/india-others/swine-flu-deaths-at-1895-cases-near-32k-mark/	title=Swine flu deaths at 1895; number of cases near 32K mark	last=Press Trust of India	date=March 21, 2015	publisher=The Indian Express	access-date=March 21, 2015	archive-url=https://web.archive.org/web/20151012003206/http://indianexpress.com/article/india/india-others/swine-flu-deaths-at-1895-cases-near-32k-mark/	archive-date=October 12, 2015	url-status=live}}
2015–16 Zika virus epidemic	2015–2016	Worldwide	Zika virus	53
2016 Angola and Democratic Republic of the Congo yellow fever outbreak	2016	Angola and Democratic Republic of the Congo	Yellow fever	498 (377 in Angola, 121 in Congo)
2016–2022 Yemen cholera outbreak	2016–2023	Yemen	Cholera	4,004 ()
2017 Nigeria Lassa fever epidemic	2017–2023	Nigeria	Lassa fever	1103 (as of April 2023)
2017 dengue outbreak in Peshawar	2017	Peshawar, Pakistan	Dengue fever	69
2017 Gorakhpur hospital deaths	2017	India	Japanese encephalitis	1,317
2017 dengue outbreak in Sri Lanka	2017	Sri Lanka	Dengue fever	440
2018 Nipah virus outbreak in Kerala	2018	India	Nipah virus infection	17
Kivu Ebola epidemic	2018–2020	Democratic Republic of the Congo and Uganda	Ebola	2,280
2018 NDM-CRE outbreak in Italy	2018–2019	Italy	New Delhi metallo-beta-lactamase-producing Carbapenem-resistant enterobacteriaceae	31 (as of September 2019)
2019–2020 measles outbreak in the Democratic Republic of the Congo	2019–2020	Democratic Republic of the Congo	Measles	7,018+
2019–2020 New Zealand measles outbreak	2019–2020	New Zealand	Measles	2	date=24 February 2020	title=Measles weekly report	url=https://surv.esr.cri.nz/PDF_surveillance/MeaslesRpt/2020/measlesReport20200210.pdf	access-date=4 March 2021	website=Public Health Surveillance	archive-date=19 February 2020	archive-url=https://web.archive.org/web/20200219000610/https://surv.esr.cri.nz/PDF_surveillance/MeaslesRpt/2020/measlesReport20200210.pdf	url-status=dead }}
2019 measles outbreak in the Philippines	2019	Philippines	Measles	415
2019 Kuala Koh measles outbreak	2019	Kuala Koh, Malaysia	Measles	15
2019 Samoa measles outbreak	2019	Samoa	Measles	83	url=https://www.rnz.co.nz/international/pacific-news/406802/two-more-deaths-from-measles-in-samoa-over-new-year-period	title=Two more deaths from measles in samoa over new year period	date=2020-01-07	work=Radio New Zealand	url-status=live	archive-url=https://web.archive.org/web/20200107105921/https://www.rnz.co.nz/international/pacific-news/406802/two-more-deaths-from-measles-in-samoa-over-new-year-period	archive-date=2020-01-07}}
2019–2020 dengue fever epidemic	2019–2020	Asia-Pacific, Latin America	Dengue fever	3,931
2020 Democratic Republic of the Congo Ebola outbreak	2020	Democratic Republic of the Congo	Ebola	55
2020 dengue outbreak in Singapore	2020	Singapore	Dengue fever	32
2020 Nigeria yellow fever epidemic	2020	Nigeria	Yellow fever	296 (as of 31 December 2020)
2021 South Sudan disease outbreak	2021	South Sudan	Unknown	97 (as of December 2021)
2021 India black fungus epidemic	2021–2022	India	Black fungus (COVID-19 condition)	4,332
2022 hepatitis of unknown origin in children	2021–2022	Worldwide	Hepatitis by Adenovirus variant AF41 (Unconfirmed)	strong	18
2022–2024 Southern Africa cholera outbreak	2022–2024	Southern Africa	Cholera	11,400+
2022–2023 mpox outbreak	2022–2023	Worldwide	Mpox	280
2022 Uganda Ebola outbreak	2022–2023	Uganda	Sudan ebolavirus	77
2023–2024 Zambian cholera outbreak (part of the 2022–2024 Southern Africa cholera outbreak)	2023–2024	Zambia	Cholera	685
2023 South Poland Legionellosis outbreak	2023	Poland	Legionnaires' disease	41
2023–2024 Bangsamoro measles outbreak	2023–2024	Bangsamoro, Philippines	Measles	14
2023–2024 Oropouche virus disease outbreak	2023–2024	Brazil	Oropouche fever	2
2024 American dengue epidemic	2024	Latin America and the Caribbean	Dengue fever	9,875
2024 Kwango province malaria outbreak	2024	Democratic Republic of the Congo	Malaria	143

Ongoing

Event	Years	Location	Disease	Death toll (estimate)	Ref.
Seventh cholera pandemic	1961–present	Worldwide	Cholera (El Tor strain)	21,000–143,000 each year, millions total; 1.4-9.3 million (as of 2026)
HIV/AIDS pandemic	1981–present	Worldwide	HIV/AIDS	45 million ()
MERS outbreak	2012–present	Worldwide	Middle East respiratory syndrome / MERS-CoV	941 ()
COVID-19 pandemic	2019–present	Worldwide	COVID-19	7.13–38 million	title=The pandemic's true death toll	newspaper=The Economist	url=https://www.economist.com/graphic-detail/coronavirus-excess-deaths-estimates	archive-url=https://web.archive.org/web/20240208015904/https://www.economist.com/graphic-detail/coronavirus-excess-deaths-estimates	date=26 July 2023	archive-date=8 February 2024}}
2023–2025 mpox epidemic	2023–present	Worldwide, primarily Africa	Mpox	812
2024–2025 Sudanese cholera epidemic	2024–present	Sudan, South Sudan, and Chad	Cholera	9,224

Explanatory notes

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