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ZEB2-AS1

ZEB2-AS1 (ZEB2 antisense RNA 1) is a long non-coding RNA, which is overlapping and antisense to the ZEB2 gene. It overlaps the 5′ splice site of an intron within the 5′UTR of the ZEB2 gene. This intron contains an internal ribosome entry site (IRES), which is necessary for ZEB2 expression. ZEB2-AS1 prevents the splicing of this intron, and therefore activates ZEB2 expression.

References

(October 2003). "Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1". Genomics.
(March 2008). "A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition". Genes Dev..

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

non-coding-rna

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