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YceI protein domain

Field	Value
Symbol	YceI
Name	YceI
image	PDB 1wub EBI.jpg
caption	Crystal structure of the polyisoprenoid-binding protein, TT1927B, from Thermus thermophilus hb8
Pfam	PF04264
InterPro	IPR007372
SCOP	1uf6
OPM family	101
OPM protein	3hpe

In molecular biology, Yce-I protein domain is a putative periplasmic protein. This entry represents the lipid-binding protein YceI from Escherichia coli and the polyisoprenoid-binding protein TTHA0802 from Thermus thermophilus. Its role is to help aid the biosynthesis of isoprenoid, an important molecule found in all living organisms.

Structure

Both of these proteins share a common domain with an 8-stranded beta-barrel fold. This resembles the lipocalin fold, although no sequence homology exists with lipocalins. In TTHA0802, the protein binds the polyisoprenoid chain within the pore of the barrel via hydrophobic interactions. Sequence homologues of this core structure are present in a wide range of bacteria and archaea.

Function

The crystal structures suggests that this family of proteins plays an important role in isoprenoid quinone metabolism or in transport or storage. In both cases, the protein is a homodimer, each monomer being characterized by a lipocalin fold.

References

(August 2002). "pH-dependent expression of periplasmic proteins and amino acid catabolism in Escherichia coli". J. Bacteriol..
(April 2005). "Crystal structure of a novel polyisoprenoid-binding protein from Thermus thermophilus HB8". Protein Sci..

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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