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Vitamin D3 24-hydroxylase

Class of enzymes

Class of enzymes

FieldValue
NameVitamin D3 24-hydroxylase
EC_number1.14.15.16

Vitamin D3 24-hydroxylase (, CYP24A1) is an enzyme with systematic name calcitriol,NADPH:oxygen oxidoreductase (24-hydroxylating). This enzyme catalyses the following chemical reaction

: (1) calcitriol + NADPH + H+ + O2 \rightleftharpoons calcitetrol + NADP+ + H2O : (2) calcidiol + NADPH + H+ + O2 \rightleftharpoons secalciferol + NADP+ + H2O

Vitamin D3 24-hydroxylase is a heme-thiolate enzyme (P-450).

References

References

  1. (February 2006). "Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.
  2. (July 2006). "Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats". Molecular Pharmacology.
  3. (January 2005). "Metabolism of vitamin D3 by cytochromes P450". Frontiers in Bioscience.
  4. (July 2007). "Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone". Proceedings of the National Academy of Sciences of the United States of America.
  5. (September 2004). "Metabolism of A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 by CYP24A1". Biochemical and Biophysical Research Communications.
  6. (April 2004). "Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1". Biochemistry.
  7. (December 2004). "Enzymes involved in the activation and inactivation of vitamin D". Trends in Biochemical Sciences.
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