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Vesiculovirus matrix proteins

Field	Value
Symbol	Vesiculo_matrix
Name	Vesiculo_matrix
image	PDB 1lg7 EBI.jpg
caption	crystal structure of vesicular stomatitis virus matrix protein
Pfam	PF06326
InterPro	IPR009397
SCOP	1lg7
OPM family	381
OPM protein	1lg7

The family of vesiculovirus matrix proteins consists of several matrix proteins of the vesicular stomatitis virus, also known as VSIV or VSV. The matrix (M) protein of the virus causes many of the cytopathic effects of VSV, including an inhibition of host gene expression and the induction of cell rounding. It has been shown that M protein also induces apoptosis in the absence of other viral components. It is thought that the activation of apoptotic pathways causes the inhibition of host gene expression and cell rounding by M protein.

Function

These proteins play a major role in assembly and budding of VSIV virions. Their main role is to aid virus assembly. They starts by shutting off host cell transcription by inhibiting mRNA nuclear export through direct interaction with the host RAE1-NUP98 complex. This inhibits interferon signaling and thus establishment of antiviral state in virus infected cells. In turn, this induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell. Enveloped viruses acquire their membrane by budding at a membrane of their host cell.

Structure

The structure of these matrix proteins has revealed a single-globular domain with a new fold. The N-terminal part consists of a large five-stranded anti-parallel beta-sheet packed against two alpha-helices; the C-terminal part comprises a small two stranded anti-parallel beta-sheet and an alpha-helix.

References

(May 2003). "The cell-rounding activity of the vesicular stomatitis virus matrix protein is due to the induction of cell death". J. Virol..
(2002-06-17). "Crystal structure of vesicular stomatitis virus matrix protein". The EMBO Journal.
(2005). "Membrane deformations induced by the matrix protein of vesicular stomatitis virus in a minimal system.". J Gen Virol.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

viral-structural-proteins viral-protein-class protein-families vesiculoviruses

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