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Very-long-chain 3-oxoacyl-CoA reductase

Field	Value
Name	Very-long-chain 3-oxoacyl-CoA reductase
EC_number	1.1.1.330

Very-long-chain 3-oxoacyl-CoA reductase (, very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene), IFA38 (gene)) is an enzyme with systematic name (3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction

: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ \rightleftharpoons a very-long-chain 3-oxoacyl-CoA + NADPH + H+

This microsomal complex extends palmitoyl-CoA and stearoyl-CoA (and their modified forms) to very-long-chain acyl CoAs.

References

(March 2002). "A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase". The Journal of Biological Chemistry.
(September 2002). "The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase". The Journal of Biological Chemistry.
(July 2009). "Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase". Plant Physiology.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-1.1.1

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