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Urea-containing cream
Dermatologic drug
Dermatologic drug
| Field | Value | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| image | Urea 2D & Urea 3D.png | |||||||||||||||
| caption | 2D and 3D image of urea molecule | |||||||||||||||
| tradename | Decubal, Carmol 40, Keralac, others | |||||||||||||||
| Drugs.com | ||||||||||||||||
| DailyMedID | Urea cream | |||||||||||||||
| pregnancy_AU | ||||||||||||||||
| routes_of_administration | Topical | |||||||||||||||
| ATC_prefix | D02 | |||||||||||||||
| ATC_suffix | AE01 | |||||||||||||||
| legal_AU | ||||||||||||||||
| legal_BR | ||||||||||||||||
| legal_CA | ||||||||||||||||
| legal_DE | ||||||||||||||||
| legal_NZ | ||||||||||||||||
| legal_UK | ||||||||||||||||
| legal_US | OTC | |||||||||||||||
| legal_UN | ||||||||||||||||
| legal_status | ||||||||||||||||
| CAS_number | 57-13-6 | |||||||||||||||
| ChemSpiderID | none | |||||||||||||||
| UNII | 8W8T17847W | |||||||||||||||
| C | H= | Ag= | Al= | As= | Au= | B= | Bi= | Br= | Ca= | Cl= | Co= | F= | Fe= | Gd= | I= | |
| K | Li= | Mg= | Mn= | N= | Na= | O= | P= | Pt= | S= | Sb= | Se= | Sr= | Tc= | Zn= | charge= |
| Drugs.com =
| elimination_half-life =
Urea-containing cream, also known as carbamide-containing cream, is used as a medication and applied to the skin to treat dryness and itching such as may occur in psoriasis, dermatitis, or ichthyosis. It may also be used to soften nails.
In adults side effects are generally few. It may occasionally cause skin irritation. Urea works in part by loosening dried skin. Preparations generally contain 5 to 50% urea.
Urea containing creams have been used since the 1940s. It is on the World Health Organization's List of Essential Medicines. It is available over the counter.
Medical uses
Urea cream is indicated for debridement and promotion of normal healing of skin areas with hyperkeratosis, particularly where healing is inhibited by local skin infection, skin necrosis, fibrinous or itching debris or eschar. Specific condition with hyperkeratosis where urea cream is useful include:
- Dry skin and rough skin
- Dermatitis
- Psoriasis
- Ichthyosis
- Eczema
- Keratosis
- Keratoderma
- Corns
- Calluses
- Damaged, ingrown and devitalized nails
Side effects
Common side effects of urea cream are:
- Mild skin irritation
- Temporary burning sensation
- Stinging sensation
- Itching
In severe cases, there can be an allergic reaction with symptoms such as skin rash, urticaria, difficulty breathing and swelling of the mouth, face, lips, or tongue.
Mechanism of action
Urea in low doses is a humectant while at high doses (above 20%) it causes breakdown of protein in the skin.
Urea dissolves the intercellular matrix of the cells of the stratum corneum, promoting desquamation of scaly skin, eventually resulting in softening of hyperkeratotic areas. In nails, urea causes softening and eventually debridement of the nail plate.
References
References
- (2015). "British national formulary : BNF 69". British Medical Association.
- "Urea topical medical facts from Drugs.com".
- (2015). "European Handbook of Dermatological Treatments". Springer.
- (2009). "WHO Model Formulary 2008". World Health Organization.
- "Urea Cream - FDA prescribing information, side effects and uses".
- (1999). "Dry Skin and Moisturizers: Chemistry and Function". CRC Press.
- (2025). "The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list". World Health Organization.
- (4 May 2011). "Urea Cream (Consumer Information)". Drugs.com.
- (2016). "Moisturizers: The Slippery Road". Indian Journal of Dermatology.
This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.
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