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UDP-N-acetylglucosamine kinase

Class of enzymes

Class of enzymes

FieldValue
NameUDP-N-acetylglucosamine kinase
EC_number2.7.1.176

UDP-N-acetylglucosamine kinase (, UNAG kinase, zeta toxin, toxin PezT, ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase) is an enzyme with systematic name ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase. This enzyme catalyses the following chemical reaction

: ATP + UDP-N-acetyl-alpha-D-glucosamine \rightleftharpoons ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate

The phosphorylation of UDP-N-acetyl-D-glucosamine causes the inhibition of enzyme EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase.

These enzymes are found as part of plasmid-encoded and chromosomal bacterial toxin-antitoxin systems.

References

References

  1. (March 2011). "A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis". PLOS Biology.
  2. (August 2015). "A cis-acting antitoxin domain within the chromosomal toxin-antitoxin module EzeT of Escherichia coli quenches toxin activity". Molecular Microbiology.
  3. (September 2005). "The toxin-antitoxin system of the streptococcal plasmid pSM19035". Journal of Bacteriology.
  4. (July 2007). "Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae". The Journal of Biological Chemistry.
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