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UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase

Class of enzymes

Class of enzymes

FieldValue
NameUDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase
EC_number1.1.1.335

UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase (, WlbA, WbpB) is an enzyme with systematic name UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate:NAD+ 3-oxidoreductase. This enzyme catalyses the following chemical reaction:

: UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate + NAD+ \rightleftharpoons UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + NADH + H+

This enzyme participates in the biosynthesis of lipopolysaccharide UDP-alpha-D-ManNAc3NAcA.

References

References

  1. (May 2009). "Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa". The Journal of Biological Chemistry.
  2. (June 2009). "Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1". Biochemistry.
  3. (September 2010). "Structural and functional studies of WlbA: A dehydrogenase involved in the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid". Biochemistry.
  4. (March 2011). "Biochemical and structural characterization of WlbA from Bordetella pertussis and Chromobacterium violaceum: enzymes required for the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid". Biochemistry.
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