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Tyrosine N-monooxygenase

Class of enzymes

Summary

Class of enzymes

Field	Value
Name	Tyrosine N-monooxygenase
EC_number	1.14.13.41
CAS_number	159447-19-5

Tyrosine N-monooxygenase (, tyrosine N-hydroxylase, CYP79A1) is an enzyme with systematic name L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

:L-tyrosine + 2 O2 + 2 NADPH + 2 H+ \rightleftharpoons (Z)-[4-hydroxyphenylacetaldehyde oxime] + 2 NADP+ + CO2 + 3 H2O (overall reaction) :(1a) L-tyrosine + O2 + NADPH + H+ \rightleftharpoons N-hydroxy-L-tyrosine + NADP+ + H2O :(1b) N-hydroxy-L-tyrosine + O2 + NADPH + H+ \rightleftharpoons N,N-dihydroxy-L-tyrosine + NADP+ + H2O :(1c) N,N-dihydroxy-L-tyrosine \rightleftharpoons (Z)-[4-hydroxyphenylacetaldehyde oxime] + CO2 + H2O

Tyrosine N-monooxygenase is heme-thiolate protein (P-450).

References

(December 1990). "The biosynthesis of cyanogenic glucosides in higher plants. Identification of three hydroxylation steps in the biosynthesis of dhurrin in Sorghum bicolor (L.) Moench and the involvement of 1-ACI-nitro-2-(p-hydroxyphenyl)ethane as an intermediate". The Journal of Biological Chemistry.
(February 1995). "Cytochrome P-450TYR is a multifunctional heme-thiolate enzyme catalyzing the conversion of L-tyrosine to p-hydroxyphenylacetaldehyde oxime in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench". The Journal of Biological Chemistry.
(August 2000). "Transgenic tobacco and Arabidopsis plants expressing the two multifunctional sorghum cytochrome P450 enzymes, CYP79A1 and CYP71E1, are cyanogenic and accumulate metabolites derived from intermediates in Dhurrin biosynthesis". Plant Physiology.
(April 2000). "Cloning and expression of cytochrome P450 enzymes catalyzing the conversion of tyrosine to p-hydroxyphenylacetaldoxime in the biosynthesis of cyanogenic glucosides in Triglochin maritima". Plant Physiology.
(July 2002). "Dhurrin synthesis in sorghum is regulated at the transcriptional level and induced by nitrogen fertilization in older plants". Plant Physiology.
(February 2005). "Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome". Proceedings of the National Academy of Sciences of the United States of America.

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ec-1.14.13

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