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Tulobuterol

Chemical compound

Summary

Chemical compound

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| elimination_half-life =

"Hokunarin Tape" used to treat asthma and bronchitis

Tulobuterol (INN) is a long-acting beta2-adrenergic receptor agonist, marketed in Japan as a transdermal patch under the name Hokunalin tape (ホクナリンテープ).

Currently, it is only legal in 7 countries: Japan, Germany, China, South Korea, Bangladesh, Pakistan, and Venezuela. It is available in India also.

Synthesis

:[[File:Tulobuterol synthesis.svg|500px|class=skin-invert-image]]

The oxidation of 2'-chloroacetophenone (1) with selenium dioxide gives o-chlorophenylglyoxal (2). Condensation with tert-butylamine gives the imine (3). Reduction with sodium borohydride completes the synthesis of tulobuterol.

References

(2011). "Clinical evaluation of a transdermal therapeutic system of the beta2-agonist tulobuterol in patients with mild or moderate persistent bronchial asthma". Arzneimittel-Forschung.
(2023). "Development of a New Process for Tulobuterol Hydrochloride". Pharmaceutical Fronts.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

beta-adrenergic-agonists phenylethanolamines 2-chlorophenyl-compounds

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