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TUC338

Field	Value
Name	TUC338
Symbol	TUC338
RNA_type	Gene
Tax_domain	Vertebrata
Chromosome	12
Arm	q

TUC338 (transcribed ultra-conserved region 338) is an ultra-conserved element which is transcribed to give a non-coding RNA. The TUC338 gene was first identified as uc.338, along with 480 other ultra-conserved elements in the human genome. Expression of this RNA gene has been found to dramatically increase in hepatocellular carcinoma (HCC) cells.

The TUC338 RNA gene is 590 base-pairs long, and partially overlaps the gene encoding Poly(rC)-binding protein 2 (PCBP2), a protein involved in mRNA processing. Despite this overlap, PCBP2 and TUC388 were found to be independently expressed.

TUC338 is predicted to function in cell growth, possibly at the interface between G1 phase and S phase, and could potentially present a therapeutic target to treat HCC cells. Experimental evidence shows knocking out TUC338 using siRNA reduced the growth rate of both mouse and human HCC cells.

References

(September 2007). "Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas". Cancer Cell.
(May 2006). "A distal enhancer and an ultraconserved exon are derived from a novel retroposon". Nature.
(May 2004). "Ultraconserved elements in the human genome". Science.
(January 2011). "Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America.
(March 1999). "Identification of the poly(C) binding protein in the complex associated with the 3′ untranslated region of erythropoietin messenger RNA". Blood.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

non-coding-rna

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