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Tuaminoheptane

Sympathomimetic agent

Summary

Sympathomimetic agent

| elimination_half-life =

6240-90-0 ((R)-isomer) 44745-29-1 ((S)-isomer) (combinations)

Tuaminoheptane (, ; brand names Heptin, Heptadrine, Tuamine; also known as tuamine and 2-aminoheptane) is a sympathomimetic agent and vasoconstrictor which is used as a nasal decongestant. It has also been used as a stimulant.

Tuaminoheptane has been found to act as a reuptake inhibitor and releasing agent of norepinephrine, which may underlie its decongestant and stimulant effects. It is an alkylamine. The chemical structure of the drug differs from that of other norepinephrine releasing agents, such as the phenethylamines, which, in contrast to tuaminoheptane, have an aromatic ring in their structure.

Tuaminoheptane is on the 2011 list of prohibited substances published by the World Anti-Doping Agency.

References

References

  1. (25 March 2005). "tuamine - Compound Summary". National Center for Biotechnology Information.
  2. (14 November 2014). "The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies". Springer.
  3. (6 December 2012). "Concise Dictionary of Pharmacological Agents: Properties and Synonyms". Springer Science & Business Media.
  4. (September 1958). "Adrenergic drugs and their antagonists". Postgraduate Medicine.
  5. (March 2010). "Stimulants and doping in sport". Endocrinology and Metabolism Clinics of North America.
  6. (August 1990). "Effect of tuamine, heptaminol and two analogues on uptake and release of catecholamines in cultured chromaffin cells". Biochemical Pharmacology.
  7. (September 2011). "Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET". Proceedings of the National Academy of Sciences of the United States of America.
  8. (June 2008). "Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA)". British Journal of Pharmacology.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

alkylamines decongestants ion-channel-blockers norepinephrine-releasing-agents stimulants
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