Surf Wiki
Save to docs
general/vaccines

From Surf Wiki (app.surf) — the open knowledge base

Trypanosomiasis vaccine

Efforts to develop a vaccine for trypanosomiasis

Efforts to develop a vaccine for trypanosomiasis

A Trypanosomiasis vaccine is a vaccine against trypanosomiasis. No effective vaccine currently exists, but development of a vaccine is the subject of current research.

The Gates Foundation has been involved in funding research conducted by the Sabin Vaccine Institute and others.

There are many obstacles to development of such a vaccine. One obstacle is variant surface glycoprotein, which makes it difficult for the immune system to recognize the infectious organism. Also, Trypanosoma brucei has a direct inhibitory effect upon B cells.

It has been suggested that these challenges could be overcome by a vaccine against the initial antigens, or generating an immune response against the cysteine protease (for example, cruzipain).

An effective vaccine was achieved in 2021 using a mouse model of infection with Trypanosoma vivax.

References

References

  1. "US Fraunhofer Center receives Grant from the Bill & Melinda Gates Foundation-Intellectual Property".
  2. (January 2009). "T-Cell Responses to the Trypanosome Variant Surface Glycoprotein Are Not Limited to Hypervariable Subregions". Infect. Immun..
  3. (May 2008). "Trypanosomiasis-Induced B Cell Apoptosis Results in Loss of Protective Anti-Parasite Antibody Responses and Abolishment of Vaccine-Induced Memory Responses". PLOS Pathog..
  4. "Trypanosomiasis".
  5. (May 2002). "Congopain from Trypanosoma congolense: drug target and vaccine candidate". Biol. Chem..
  6. (November 2001). "Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: targeting the disease rather than the parasite". Int. J. Parasitol..
  7. (July 2021). "An invariant Trypanosoma vivax vaccine antigen induces protective immunity". Nature.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

vaccines
Want to explore this topic further?

Ask Mako anything about Trypanosomiasis vaccine — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report