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TRNA (guanine37-N1)-methyltransferase

FieldValue
NametRNA (guanine37-N1)-methyltransferase
EC_number2.1.1.228

tRNA (guanine37-N1)-methyltransferase (, TrmD, tRNA (m1G37) methyltransferase, transfer RNA (m1G37) methyltransferase, Trm5p, TRMT5, tRNA-(N1G37) methyltransferase, MJ0883 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine37-N1)-methyltransferase. This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + guanine37 in tRNA \rightleftharpoons S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA

This enzyme is important for the maintenance of the correct reading frame during translation.

References

References

  1. (December 2006). "The substrate specificity of tRNA (m1G37) methyltransferase (TrmD) from ''Aquifex aeolicus''". Genes to Cells.
  2. (September 2007). "Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase". The Journal of Biological Chemistry.
  3. (April 2004). "Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth". Journal of Bacteriology.
  4. (July 2004). "Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein". Biochemistry.
  5. (September 2008). "Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5". Proteins.
  6. (June 2003). "Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition". The EMBO Journal.
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