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TRNA (guanine26-N2)-dimethyltransferase

FieldValue
NameTRNA (guanine26-N2)-dimethyltransferase
EC_number2.1.1.216

TRNA (guanine26-N2)-dimethyltransferase (, Trm1p, TRM1, tRNA (m22G26)dimethyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine26-N2)-dimethyltransferase. This enzyme catalyses the following chemical reaction

: 2 S-adenosyl-L-methionine + guanine26 in tRNA \rightleftharpoons 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA

The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions.

References

References

  1. (August 1999). "Characterisation and enzymatic properties of tRNA(guanine 26, N (2), N (2))-dimethyltransferase (Trm1p) from Pyrococcus furiosus". Journal of Molecular Biology.
  2. (August 1998). "The tRNA(guanine-26,N2-N2) methyltransferase (Trm1) from the hyperthermophilic archaeon Pyrococcus furiosus: cloning, sequencing of the gene and its expression in Escherichia coli". Nucleic Acids Research.
  3. (November 1998). "Point and deletion mutations eliminate one or both methyl group transfers catalysed by the yeast TRM1 encoded tRNA (m22G26)dimethyltransferase". Nucleic Acids Research.
  4. (January 1999). "Caenorhabditis elegans ZC376.5 encodes a tRNA (m2/2G(26))dimethyltransferance in which (246)arginine is important for the enzyme activity". Gene.
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