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TRNA (cytosine34-C5)-methyltransferase

Field	Value
Name	TRNA (cytosine34-C5)-methyltransferase
EC_number	2.1.1.203

TRNA (cytosine34-C5)-methyltransferase (, hTrm4 Mtase, hTrm4 methyltransferase, hTrm4 (gene), tRNA:m5C-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase. This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + cytosine34 in tRNA precursor \rightleftharpoons S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor

The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors.

References

(2006). "Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA)". Nucleic Acids Research.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-2.1.1

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