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TRNA (adenine57-N1/adenine58-N1)-methyltransferase

Field	Value
Name	TRNA (adenine57-N1/adenine58-N1)-methyltransferase
EC_number	2.1.1.219

TRNA (adenine57-N1/adenine58-N1)-methyltransferase (, TrmI, PabTrmI, AqTrmI, MtTrmI) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine57/adenine58-N1)-methyltransferase. This enzyme catalyses the following chemical reaction:

:2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA \rightleftharpoons 2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA

The enzyme catalyses the formation of N1-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs .

References

(2004). "A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase". Nucleic Acids Research.
(October 2010). "Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase". Nucleic Acids Research.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-2.1.1

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