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Trichoepithelioma

Field	Value
name	Trichoepithelioma
synonyms	Brooke's tumour
image	Trichoepithelioma - high mag.jpg
width	150
caption	Micrograph of a trichoepithelioma. H&E stain.
field	dermatology
onset	usually young adults
diagnosis	Clinical history and examination are important. In a significant number of patients there is a familial trait. Examination will white, translucent, slightly raised papules which have a pearly white appearance.
treatment	Any suspicicion of malignant change calls for adequate excision and histological examination.

Epithelioma adenoides cysticum . The only other reason for treatment is cosmetic . Partial destruction is usually followed by regrowth. Many treatment modalities may be used including surgical excision, curettage, cryotherapy and dermabrasion. High-energy pulsed carbon dioxide laser has also been advocated as a useful treatment. Trichoepithelioma is a neoplasm of the adnexa of the skin. Its appearance is similar to basal cell carcinoma.

One form has been mapped to chromosome 9p21.

Types

Trichoepitheliomas may be divided into the following types:

:* Multiple familial trichoepithelioma :* Solitary trichoepithelioma :* Desmoplastic trichoepithelioma

Pathology

Trichoepitheliomas consists of nests of basaloid cells, with palisading. They lack the myxoid stroma and artefactual clefting seen in basal cell carcinoma. Mitoses are uncommon when compared to basal cell carcinoma.

Diagnosis

Trichoepiteliomas often contain Merkel cells; an immunostain for CK20 can be used to demonstrate this.

References

"Trichoepithelioma: Overview - eMedicine Dermatology".
(August 2004). "Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene". Cancer Res..
(2006). "Andrews' Diseases of the Skin: Clinical Dermatology". Saunders Elsevier.
(2017-11-01). "Histologic Mimics of Basal Cell Carcinoma". Archives of Pathology & Laboratory Medicine.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

epidermal-nevi,-neoplasms,-and-cysts

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