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Transient neonatal diabetes

Field	Value
name	Transient neonatal diabetes
image	Autosomal dominant - en.svg
caption	Transient neonatal diabetes mellitus is inherited in an autosomal dominant manner

Transient neonatal diabetes mellitus (TNDM) is a form of neonatal diabetes presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young (MODY).

Types

Type	OMIM	Gene	Locus	Description
TNDM1	{{OMIM	601410	none}}	ZFP57, PLAGL1	6p22.1, 6q24.2
TNDM2	{{OMIM	610374	none}}	ABCC8	11p15.1
TNDM3	{{OMIM	610582	none}}	KCNJ11	11p15.1

Cause

This condition has to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).

The form on chromosome 6 can involve imprinting.

References

"OMIM Entry - # 610582 - DIABETES MELLITUS, TRANSIENT NEONATAL, 3".
(May 2008). "A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes". EMBO Rep..
Raphaël Scharfmann. (2007). "Development of the Pancreas and Neonatal Diabetes". Karger Publishers.
"Other Forms (MODY, LADA, Neonatal)". DiabetesCare.net.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

types-of-diabetes neonatology

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