Surf Wiki
Save to docs
science/chemistry

From Surf Wiki (app.surf) — the open knowledge base

Transamidation

Transamidation is a chemical reaction in which an amide reacts with an amine to generate a new amide: :RC(O)NR'2 + HNR"2 → RC(O)NR"2 + HNR'2

The reaction is rarely employed, but it could prove relevant to peptide synthesis.

Amides are characteristically inert, but the amino substituents can be exchanged in the presence of Lewis acid and organometallic catalysts. Primary amides (RC(O)NH2) are more amenable to this reaction.

Ureas

In contrast to the reluctance of amides as substrates, urea is more susceptible to this exchange process. Transamidation is practiced, sometimes even on an industrial scale, to prepare a variety of N-substituted ureas: :(H2N)2CO + R2NH → (R2N)(H2N)CO + NH3 :(R2N)(H2N)CO + R2NH → (R2N)2CO + NH3 Methylurea, precursor to theobromine, is produced from methylamine and urea. Phenylurea is produced similarly but from anilinium chloride:{{cite journal :(H2N)2CO + [C6H5NH3]Cl → (C6H5(H)N)(H2N)CO + NH4Cl

Hydrazine derivatives of urea are often produced by transamidation-like reactions. These products include carbohydrazide, semicarbazide, and biurea.

References

References

  1. (2011). "Rethinking amide bond synthesis". Nature.
  2. Emma L. Baker. (2016). "A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis". Nature Communications.
  3. C. Nitschke. (2012). "Urea Derivatives".
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

amides chemical-reactions
Want to explore this topic further?

Ask Mako anything about Transamidation — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report