From Surf Wiki (app.surf) — the open knowledge base
Tiletamine
Chemical compound
Chemical compound
| Field | Value | |
|---|---|---|
| Verifiedfields | changed | |
| verifiedrevid | 470610310 | |
| IUPAC_name | 2-Ethylamino-2-(2-thienyl)cyclohexanone | |
| image | Tiletamine Structure.svg | |
| image_class | skin-invert-image | |
| image2 | Tiletamine-ball-and-stick-model.png | |
| image_class2 | bg-transparent | |
| alt2 | (S)-tiletamine | |
| Drugs.com | ||
| pregnancy_AU | ||
| pregnancy_US | ||
| legal_AU | S4 | |
| legal_CA | ||
| legal_UK | ||
| legal_US | Schedule III (when combined with Zolazepam) | |
| routes_of_administration | IV, IM, SC, Other | |
| metabolism | Liver | |
| excretion | Kidneys | |
| <!--Identifiers--> | index2_label | HCl |
| CAS_number_Ref | ||
| CAS_number | 14176-49-9 | |
| CAS_number2_Ref | ||
| CAS_number2 | 14176-50-2 | |
| UNII_Ref | ||
| UNII | 2YFC543249 | |
| UNII2_Ref | ||
| UNII2 | 99TAQ2QWJI | |
| ATC_prefix | none | |
| PubChem | 26533 | |
| DrugBank_Ref | ||
| ChemSpiderID_Ref | ||
| ChemSpiderID | 24714 | |
| KEGG_Ref | ||
| KEGG | D08596 | |
| <!--Chemical data--> | C | 12 |
| H | 17 | |
| N | 1 | |
| O | 1 | |
| S | 1 | |
| smiles | O=C2C(c1sccc1)(NCC)CCCC2 | |
| StdInChI_Ref | ||
| StdInChI | 1S/C12H17NOS/c1-2-13-12(11-7-5-9-15-11)8-4-3-6-10(12)14/h5,7,9,13H,2-4,6,8H2,1H3 | |
| StdInChIKey_Ref | ||
| StdInChIKey | QAXBVGVYDCAVLV-UHFFFAOYSA-N |
| Drugs.com =
| elimination_half-life =
Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is related chemically to ketamine. Tiletamine hydrochloride exists as odorless white crystals.
It is used in veterinary medicine in the combination product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs. It is sometimes used in combination with xylazine (Rompun) to chemically immobilize large mammals such as polar bears and wood bison. Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.
Society and culture
Recreational use of telazol has been documented. Animal studies have also shown that tiletamine produces rewarding and reinforcing effects. Products that combine Tiletamine and Zolazepam are classified as Schedule III controlled substances in the United States. Otherwise, as noted by the DEA, tiletamine is unscheduled: “…[R]ules applicable to the scheduling of tiletamine and zolazepam as individual entities are not warranted [or in effect] at this time. Neither tiletamine nor zolazepam, as discrete substances, is perceived to pose a significant threat to the health and general welfare at this time…”
References
References
- (October 1988). "Paradoxical convulsant action of a novel non-competitive N-methyl-D-aspartate (NMDA) antagonist, tiletamine". Brain Research.
- {{PubChem. 26533
- "Tiletamine". Drugs.com.
- (December 1993). "Telazol--a review of its pharmacology and use in veterinary medicine". Journal of Veterinary Pharmacology and Therapeutics.
- (21 January 2009). "Tiletamine". U.S. National Library of Medicine.
- (July 2003). "Anesthesia of polar bears using xylazine-zolazepam-tiletamine or zolazepam-tiletamine". Journal of Wildlife Diseases.
- (January 2000). "Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations". The Canadian Veterinary Journal.
- (2001). "Abuse of telazol: an animal tranquilizer". Journal of Toxicology. Clinical Toxicology.
- (August 2012). "Rewarding and reinforcing effects of the NMDA receptor antagonist-benzodiazepine combination, Zoletil®: difference between acute and repeated exposure". Behavioural Brain Research.
- "Lists of: Scheduling Actions, Controlled Substances, Regulated Chemicals". Drug Enforcement Administration.
- (January 21, 1987). "Schedules of Controlled Substances: Placement of Preparations Which Contain Both Tiletamine and Zolazepam into Schedule III". [[Drug Enforcement Administration]].
This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.
Ask Mako anything about Tiletamine — get instant answers, deeper analysis, and related topics.
Research with MakoFree with your Surf account
Create a free account to save articles, ask Mako questions, and organize your research.
Sign up freeThis content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.
Report