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Tiapamil

Chemical compound

Summary

Chemical compound

Field	Value
type
image	Dimeditiapramine.svg
image_class	skin-invert-image
image2	Dimeditiapramine 3D spacefill.png
image_class2	bg-transparent
pregnancy_AU
ATC_prefix
legal_AU
legal_BR
legal_CA
legal_DE
legal_NZ
legal_UK
legal_US
legal_UN
legal_status
CAS_number_Ref
CAS_number	57010-31-8
PubChem	42107
ChemSpiderID_Ref
ChemSpiderID	38399
UNII_Ref
UNII	0ONY823T4J
smiles	CN(CCCC1(S(=O)(=O)CCCS1(=O)=O)C2=CC(=C(C=C2)OC)OC)CCC3=CC(=C(C=C3)OC)OC
synonyms	Dimeditiapramine; Ro 11-1781
IUPAC_name	2-(3,4-Dimethoxyphenyl)-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]methylamino}propyl)-1λ6,3λ6-dithiane-1,1,3,3-tetrone
C	26	H=37	N=1	O=8	S=2

| Drugs.com = | elimination_half-life =

Tiapamil (INN; also known as dimeditiapramine) is a calcium antagonist or calcium channel blocker. It is an experimental drug that has never been marketed.

Tiapamil has been described as an antianginal agent. It exhibits properties of anti-arrhythmic medications. These are medications that are used to treat unusually fast or irregular heartbeats. Examples of arrhytmthic conditions include atrial fibrillation, atrial flutter, and super-ventricular tachycardia. Upon research, the drug shows promising effects on treatment of these condition. Research seeks to create a treatment with tiapamil in order to mitigate the side effects of the more commonly prescribed calcium antagonist and anti-hypertensive verapamil. The two drugs have similar properties; however, tiapamil appears to treat arrhythmic conditions without many of the hypotensive, negative inotropic, and negative chronotropic side effects. Tiapamil is a calcium channel blocker that acts on the slow calcium channels. It can treat ventricular arrhythmias to a higher degree than traditional calcium antagonists.

References

(June 1979). "Human electropharmacology of the calcium antagonist dimeditiapramine (Ro 11-1781) in coronary patients". Clinical Cardiology.
(December 1980). "Antiarrhythmic effect of the calcium antagonist tiapamil (Ro 11-1781) by intravenous administration in patients with coronary heart disease". Clinical Cardiology.
"Tiapamil". Springer Nature Switzerland AG.
(April 1979). "Dimeditiapramine (Ro 11-1781), a new calcium antagonist, in the management of supraventricular tachyarrhythmias in patients with acute myocardial infarction". Clinical Cardiology.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

antianginals calcium-channel-blockers catechol-ethers dithianes methoxyphenethylamines

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