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Thiosemicarbazone

Class of chemical compounds

Thiosemicarbazone
Summary

Class of chemical compounds

General chemical structure of a thiosemicarbazone

A thiosemicarbazone is an organosulfur compound with the formula H2NC(S)NHN=CR2. Many variations exist, including those where some or all of the NH centers are substituted by organic groups. Thiosemicarbazones are usually produced by condensation of a thiosemicarbazide with an aldehyde or ketone: : H2NC(S)NHNH2 + O=CR2 → H2NC(S)NHN=CR2 + H2O In terms of their chemical structures, the CSN3 core atoms are coplanar.

Occurrence and applications

Some thiosemicarbazones have medicinal properties, e.g. the antiviral metisazone and the antibiotic thioacetazone. Thiosemicarbazones are also widely used as ligands in coordination chemistry. The affinity of thiosemicarbazones for metal ions is exploited in controlling iron overload.

References

References

  1. (2012). "Iodido[1-(propan-2-ylidene)thiosemicarbazide-κS]bis(triphenylphosphane-κP)copper(I)". Acta Crystallographica Section E.
  2. (1975). "Transition metal complexes of thiosemicarbazide and thiosemicarbazones". Coordination Chemistry Reviews.
  3. (2013). "Novel Chelators for Cancer Treatment: Where Are We Now?". Antioxidants & Redox Signaling.
Wikipedia Source

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thiosemicarbazones functional-groups semicarbazides
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