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Thelephoric acid

Thelephoric acid is a terphenylquinone pigment that is found in several fungi, such as Omphalotus subilludens and Polyozellus multiplex. Thelephoric acid has been shown to inhibit prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects. It is derived from atromentin, and its precursor can be from cyclovariegatin. Fragmentation patterns have suggested that polymers of thelephoric acid exists.

References

References

  1. (1997). "Polyozellin, a new inhibitor of prolyl endopeptidase from ''Polyozellus multiplex''". The Journal of Antibiotics.
  2. (1999). "Thelephoric acid and kynapcin-9 in mushroom ''Polyozellus multiflex'' inhibit prolyl endopeptidase ''in vitro''". Journal of Microbiology and Biotechnology.
  3. (2014). "Potential anti-angiogenesis effects of ''p''-terphenyl compounds from ''Polyozellus multiplex''". Journal of Natural Products.
  4. (1971). "Occurrence of atromentin and thelephoric acid in cultures of ''Clitocybe subilludens''". Journal of Pharmaceutical Sciences.
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tetrols quinones hydrolase-inhibitors catechols dibenzofurans heterocyclic-compounds-with-5-rings aromatic-ketones fungal-pigments
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