Surf Wiki
Save to docs
general/opioids

From Surf Wiki (app.surf) — the open knowledge base

TAN-67

Chemical compound

Chemical compound

TAN-67 (SB-205,607) is an opioid drug used in scientific research that acts as a potent and selective δ-opioid agonist, selective for the δ1 subtype. It has analgesic properties and induces dopamine release in nucleus accumbens. It also protects both heart and brain tissue from hypoxic tissue damage through multiple mechanisms involving among others an interaction between δ receptors and mitochondrial K(ATP) channels.

References

References

  1. (2001). "Synthesis of optically active TAN-67, a highly selective delta opioid receptor agonist, and investigation of its pharmacological properties". Drug Design and Discovery.
  2. (November 1998). "Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl- 1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67)". Chemical & Pharmaceutical Bulletin.
  3. (December 2000). "Modulation of NMDA- and (+)TAN-67-induced nociception by GABA(B) receptors in the mouse spinal cord". Life Sciences.
  4. (April 2001). "The pharmacological profile of delta opioid receptor ligands, (+) and (-) TAN-67 on pain modulation". Life Sciences.
  5. (2005). "The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals". Neuroscience.
  6. (August 2000). "Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels". The Journal of Pharmacology and Experimental Therapeutics.
  7. (January 2001). "Protection of cardiac myocytes via delta(1)-opioid receptors, protein kinase C, and mitochondrial K(ATP) channels". American Journal of Physiology. Heart and Circulatory Physiology.
  8. (September 2002). "Delta opioid agonists and volatile anesthetics facilitate cardioprotection via potentiation of K(ATP) channel opening". FASEB Journal.
  9. (2006). "[Delta-opioid receptor activation prevents appearance of irreversible damages of cardiomyocytes and exacerbates myocardial contractility dysfunction during ischemia and reperfusion]". Patologicheskaia Fiziologiia I Eksperimental'naia Terapiia.
  10. (August 2008). "[Effects of intracerebroventricular injection of delta-opioid receptor agonist TAN-67 or antagonist naltrindole on acute cerebral ischemia in rat]". Sheng Li Xue Bao.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

opioids delta-opioid-receptor-agonists 3-hydroxyphenyl-compounds
Want to explore this topic further?

Ask Mako anything about TAN-67 — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report