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Sumatriptan/naproxen
Pharmaceutical product
Pharmaceutical product
| Field | Value |
|---|---|
| type | combo |
| component1 | Sumatriptan |
| class1 | Triptan |
| component2 | Naproxen |
| class2 | Nonsteroidal anti-inflammatory drug (NSAID) |
| tradename | Treximet, Suvexx, others |
| Drugs.com | |
| licence_EU | |
| DailyMedID | Sumatriptan naproxen |
| pregnancy_AU | |
| routes_of_administration | By mouth |
| ATC_prefix | N02 |
| ATC_suffix | CC51 |
| legal_AU | |
| legal_BR | |
| legal_CA | Rx-only |
| legal_CA_comment | |
| legal_DE | |
| legal_NZ | |
| legal_UK | |
| legal_US | Rx-only |
| legal_US_comment | |
| legal_UN | |
| legal_status | |
| KEGG | D11577 |
| Drugs.com =
Sumatriptan/naproxen, sold under the brand name Treximet among others, is a fixed-dose combination medication used to treat migraines. It is taken by mouth. It contains sumatriptan, as the succinate, a serotonin 5-hydroxytryptamine (5-HT) 1b/1d receptor agonist (triptan); and naproxen as the sodium salt, a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Medical uses
Sumatriptan/naproxen is indicated for the acute treatment of migraine with or without aura in people twelve years of age and older.
A Cochrane review in 2020 found that the combination of sumatriptan plus naproxen was better than placebo for relieving acute migraine attacks in adults. When the starting headache intensity was mild, 5 in 10 (50%) of people treated with the combination were pain-free at two hours compared with about 2 in 10 (18%) with placebo. Almost 6 in 10 (58%) people with moderate or severe pain who were treated with the combination had pain reduced to mild or none at two hours, compared with 3 in 10 (27%) with placebo. The combination was also better than the same dose of either drug given alone in these people. Results were 5 in 10 (52%) people with sumatriptan alone or about 4 in 10 (44%) with naproxen alone.
Side effects
Some of the listed side effects include dizziness, nausea, sleepiness, dry mouth, pain in neck, throat or jaw, numbness or tingling.
References
References
- (23 October 2014). "Regulatory Decision Summary - Suvexx".
- (14 April 2022). "Treximet- sumatriptan succinate and naproxen sodium tablet, film coated".
- (April 2016). "Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults". The Cochrane Database of Systematic Reviews.
- "Treximet". Drugs.com.
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