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Sulfur carrier protein ThiS adenylyltransferase


FieldValue
NameSulfur carrier protein ThiS adenylyltransferase
EC_number2.7.7.73

Sulfur carrier protein ThiS adenylyltransferase (, thiF (gene)) is an enzyme with systematic name ATP:(ThiS) adenylyltransferase. This enzyme catalyses the following chemical reaction

: ATP + [ThiS] \rightleftharpoons diphosphate + adenylyl-[ThiS]

This enzyme binds Zn2+. The enzyme catalyses the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine.

References

References

  1. (June 1998). "Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation". The Journal of Biological Chemistry.
  2. (July 2001). "Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: identification of an acyldisulfide-linked protein--protein conjugate that is functionally analogous to the ubiquitin/E1 complex". Proceedings of the National Academy of Sciences of the United States of America.
  3. (June 2005). "Structural analysis of Escherichia coli ThiF". Journal of Molecular Biology.
  4. (January 2006). "Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis". Biochemistry.
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