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Sulfur carrier protein ThiS adenylyltransferase
| Field | Value |
|---|---|
| Name | Sulfur carrier protein ThiS adenylyltransferase |
| EC_number | 2.7.7.73 |
Sulfur carrier protein ThiS adenylyltransferase (, thiF (gene)) is an enzyme with systematic name ATP:(ThiS) adenylyltransferase. This enzyme catalyses the following chemical reaction
: ATP + [ThiS] \rightleftharpoons diphosphate + adenylyl-[ThiS]
This enzyme binds Zn2+. The enzyme catalyses the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine.
References
References
- (June 1998). "Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation". The Journal of Biological Chemistry.
- (July 2001). "Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: identification of an acyldisulfide-linked protein--protein conjugate that is functionally analogous to the ubiquitin/E1 complex". Proceedings of the National Academy of Sciences of the United States of America.
- (June 2005). "Structural analysis of Escherichia coli ThiF". Journal of Molecular Biology.
- (January 2006). "Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis". Biochemistry.
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