Sudan ebolavirus

Nomenclature

The name Sudan ebolavirus is derived from Sudan (the country in which Sudan virus was first discovered) and the taxonomic suffix ebolavirus (which denotes an ebolavirus species).

The species was introduced in 1998 as Sudan Ebola virus.{{Cite book|last1=Netesov |editor-last=van Regenmortel |editor-first=M. H. V. |editor2-last=Fauquet |editor2-first=C. M. |editor3-last=Bishop |editor3-first=D. H. L. |editor4-last=Carstens |editor4-first=E. B. |editor5-last=Estes |editor5-first=M. K. |editor6-last=Lemon |editor6-first=S. M. |editor7-last=Maniloff |editor7-first=J. |editor8-last=Mayo |editor8-first=M. A. |editor9-last=McGeoch |editor9-first=D. J. |editor10-last=Pringle |editor10-first=C. R. |editor11-last=Wickner |editor11-first=R. B. |doi-access= free

A virus of the genus Ebolavirus is a member of the species Sudan ebolavirus if:

• it is endemic in Sudan and/or Uganda
• it has a genome with three gene overlaps (VP35/VP40, GP/VP30, VP24/L)
• it has a genomic sequence different from Ebola virus by ≥30% but different from that of Sudan virus by

Sudan virus (SUDV) is one of six known viruses within the genus Ebolavirus and one of four that capable of causing Ebola virus disease (EVD) in humans and other primates; it is the sole member of the species Sudan ebolavirus. SUDV is a Select agent, World Health Organization Risk Group 4 Pathogen (requiring Biosafety Level 4-equivalent containment), National Institutes of Health/National Institute of Allergy and Infectious Diseases Category A Priority Pathogen, Centers for Disease Control and Prevention Category A Bioterrorism Agent, and listed as a Biological Agent for Export Control by the Australia Group.

The first known outbreak of EVD caused by Sudan ebolavirus occurred in modern-day South Sudan between June and November 1976, infecting 284 people and killing 151, with the first identifiable case on 27 June 1976.{{Cite journal

Use of term

Sudan virus (abbreviated SUDV) was first described in 1977.{{cite journal |display-authors=8

Previous designations

Sudan virus was first introduced as a new "strain" of Ebola virus in 1977. In 2000, it received the designation Sudan Ebola virus{{Cite book|last1=Netesov |editor-last=van Regenmortel |editor-first=M. H. V. |editor2-last=Fauquet |editor2-first=C. M. |editor3-last=Bishop |editor3-first=D. H. L. |editor4-last=Carstens |editor4-first=E. B. |editor5-last=Estes |editor5-first=M. K. |editor6-last=Lemon |editor6-first=S. M. |editor7-last=Maniloff |editor7-first=J. |editor8-last=Mayo |editor8-first=M. A. |editor9-last=McGeoch |editor9-first=D. J. |editor10-last=Pringle |editor10-first=C. R. |editor11-last=Wickner |editor11-first=R. B. |editor-last=Fauquet |editor-first=C. M. |editor2-last=Mayo |editor2-first=M. A. |editor3-last=Maniloff |editor3-first=J. |editor4-last=Desselberger |editor4-first=U. |editor5-last=Ball |editor5-first=L. A.

Virus inclusion criteria

A virus of the species Sudan ebolavirus is a Sudan virus (SUDV) if it has the properties of Sudan ebolaviruses and if its genome diverges from that of the prototype Sudan virus, Sudan virus variant Boniface (SUDV/Bon), by ≤10% at the nucleotide level.

Disease

Main article: Ebola

SUDV is one of four ebolaviruses that causes Ebola virus disease (EVD) in humans (in the literature also often referred to as Ebola hemorrhagic fever, EHF). EVD due to SUDV infection cannot be differentiated from EVD caused by other ebolaviruses by clinical observation alone, which is why the clinical presentation and pathology of infections by all ebolaviruses is presented together on a separate page. The strain is less transmissible than Zaire ebolavirus.

In the past, SUDV has caused the following EVD outbreaks:

Vaccine development

As of 2022, there are six experimental vaccines but only three have advanced to the stage where human clinical trials have begun.

As the Public Health Agency of Canada developed a candidate RVSV vaccine for Sudan ebolavirus. Merck was developing it, but had discontinued development; Merck's monopolies on rVSV techniques, acquired with funding from GAVI, are not available to others developing rVSV vaccines.

As of 2021 GeoVax was developing MVA-SUDV-VLP, which is a modified vaccinia Ankara virus producing Sudan virus-like particles; early data from their research showed the GeoVax vaccine candidate to be 100% effective at preventing death from the Sudan ebolavirus in animals.

An adenovirus based vaccine previously licensed by GSK was donated to and further developed by the Sabin Vaccine Institute in partnership with the Vaccine Research Center at the US National Institute of Allergy and Infectious Diseases; as of October 2022, it will be offered to contacts of known SDV cases in the 2022 Uganda Ebola outbreak as part of a clinical trial.

Ecology

The ecology of SUDV is currently unclear and no reservoir host has yet been identified. Therefore, it remains unclear how SUDV was repeatedly introduced into human populations. As of 2009, bats have been suspected to harbor the virus because infectious Marburg virus (MARV), a distantly related filovirus, has been isolated from bats,{{Cite journal | editor1-last = Fouchier | editor1-first = Ron A. M. | article-number = e1000536 | doi-access = free

Molecular biology

SUDV is basically uncharacterized on a molecular level. However, its genomic sequence, and with it the genomic organization and the conservation of individual open reading frames, is similar to that of the other four known ebolaviruses. It is therefore currently assumed that the knowledge obtained for EBOV can be extrapolated to SUDV and that all SUDV proteins behave analogous to those of EBOV.

References

References

1. (July 2012). "Current ebola vaccines". Expert Opin Biol Ther.
2. [https://books.google.com/books?id=BbjFAAAAQBAJ&dq=Nzara%2C+South+Sudan&pg=PA61 Nzara, South Sudan]
3. "Home".
4. Biryabarema, Elias. (2022-09-22). "Uganda has confirmed seven Ebola cases so far, one death". Reuters.
5. (2014-08-24). "Ebola outbreak: DR Congo confirms two deaths". BBC.
6. "Ebola Disease caused by Sudan virus – Uganda".
7. (2014-08-24). "Ebola outbreak: DR Congo confirms two deaths". BBC.
8. Helen Branswell. (2022-09-29). "Ebola experimental vaccine trial may begin soon in Uganda".
9. (2018-09-25). "MSF's response to CEPI's policy regarding equitable access".
10. (2021-07-21). "GeoVax Announces Presentation of Sudan Ebolavirus Vaccine Data at the American Society for Virology Annual Meeting". Yahoo Finance.