From Surf Wiki (app.surf) — the open knowledge base

Sticky platelet syndrome

Field	Value
specialty	hematology

Sticky platelet syndrome (SPS) is a heritable disorder of platelet function in which platelet hyperaggregation leads to hypercoagulability. It was first described by Mammen in 1983. It is inherited in an autosomal dominant pattern. It has not been associated with a specific gene, and it is not recognized as an entity in OMIM.

It can present in conjunction with protein S deficiency and factor V Leiden. It is not currently known if sticky platelet syndrome is a distinct condition, or if it represents part of the presentation of a more well characterized coagulation disorder.

SPS has not been widely studied and is not widely known.

Signs and symptoms

Symptoms are related to hypercoagulability, usually presenting as venous thromboembolisms, arterial thrombosis, myocardial infarction, angina, and stroke.

Cause

The syndrome is believed to be hereditary.

Diagnosis

SPS is diagnosed by demonstrating platelet hyperaggregability. In a lab test called aggregometry, platelet stickiness is stimulated with epinephrine (EPI) and/or adenosine diphosphate (ADP). This test is not possible for patients being treated with acetylsalicylic acid until that substance has sufficiently cleared from their system.

Treatment

Treatment usually consists of a daily low dose (80–100 mg) of aspirin. Anticoagulants (e.g. warfarin) or antiplatelets (clopidogrel) are often additionally prescribed following formation of a medically significant clot. Thrombelastography is more commonly being used to diagnose hypercoagulability and monitor anti-platelet therapy.

References

(1999). "Sticky platelet syndrome". Seminars in Thrombosis and Hemostasis.
(February 2003). "Sticky platelet syndrome and thrombocythemia". Hematology/Oncology Clinics of North America.
(July 2009). "Bilateral simultaneous anterior ischaemic optic neuropathy associated with Sticky Platelet Syndrome". The British Journal of Ophthalmology.
(1988). ""Sticky platelet syndrome": a congenital platelet abnormality predisposing to thrombosis?". Folia Haematologica.
(July 2007). "Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients". American Journal of Transplantation.
(2006). "Hematological complications in obstetrics, pregnancy, and gynecology". Cambridge University Press.
(2008). "Obstetric anesthesia and uncommon disorders". Cambridge University Press.
(1999). "Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes". Cerebrovascular Diseases.
(January 2022). "A new decade awaits sticky platelet syndrome: where are we now, how do we manage and what are the complications?". Expert Review of Hematology.
(2018). "Sticky Platelet Syndrome: An Unrecognized Cause of Acute Thrombosis and Graft Loss". Case Reports in Nephrology.
(September 2002). "Enhanced platelet aggregation with TRAP-6 and collagen in platelet aggregometry in patients with venous thromboembolism". Thrombosis Research.
(1999). "Sticky platelet syndrome". Seminars in Thrombosis and Hemostasis.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

coagulopathies syndromes-affecting-blood

Want to explore this topic further?

Ask Mako anything about Sticky platelet syndrome — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report