Surf Wiki
Save to docs
general/syndromes

From Surf Wiki (app.surf) — the open knowledge base

Stauffer syndrome

FieldValue
nameStauffer syndrome
fieldhepatology

Stauffer syndrome is a constellation of signs and symptoms of liver dysfunction that arises due to presence of renal cell carcinoma, and, more rarely, in connection with other malignant neoplasms, though the specific pathogenesis is currently unknown. It is named for Dr. Maurice Stauffer, a gastroenterologist at the Mayo Clinic in Rochester, MN. The hepatic abnormalities are not due to tumor infiltration of the liver or intrinsic liver disease; they instead reflect the presence of a paraneoplastic syndrome.

Stauffer syndrome causes abnormal liver function tests, especially those that reflect the presence of cholestasis, i.e. abnormal bile flow. Hepatosplenomegaly may also be observed. The symptoms and signs resolve if the renal cell carcinoma (or another associated tumor) is successfully ablated. It is due to release of IL-6 from cancerous cell.

Eponym

Maurice H. Stauffer, M.D., a gastroenterologist at the Mayo Clinic in Rochester, MN, first characterized this syndrome in 1961, with the original name of "nephrogenic hepatomegaly."

There have been several recent articles crediting "Herbert Maurice Stauffer" for this discovery. References to "Herbert" are all erroneous. Dad's H is for "Havelyn". Maurice H. Stauffer Jr. (son) 4/30/2025

References

References

  1. (1978). "[Stauffer's syndrome. Reversible hepatic dysfunction in renal cell carcinoma (author's transl)]". Wien Klin Wochenschr.
  2. Stauffer MH. (1961). "Nephrogenic hepatomegaly". Gastroenterology.
  3. (July 2006). "Stauffer's Syndrome Variant with Cholestatic Jaundice A Case Report". J Gen Intern Med.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

syndromes
Want to explore this topic further?

Ask Mako anything about Stauffer syndrome — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report