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SprD

FieldValue
NameSprD
imageSprD_SScons.png
captionConserved secondary structure of SprD.
SymbolSprD
RfamRF01828
RNA_typeGene
Tax_domainStaphylococcus aureus

NOTOC In molecular biology SprD (Small pathogenicity island RNA D) is a non-coding RNA expressed on pathogenicity islands in Staphylococcus aureus. It was identified in silico along with a number of other sRNAs (SprA-G) through microarray analysis which were confirmed using a Northern blot. SprD has been found to significantly contribute to causing disease in an animal model.

Function

SprD is located between genes scn and chp in the innate immune evasion cluster (IEC) of the S. aureus genome. Its placement within this region was the first indication of a virulence-factor regulatory function.

SprD binds with sbi (Staphylococcus aureus binder of IgG) mRNA which encodes an immune evasion protein. It occludes the Shine-Dalgarno sequence and the initiation codon of sbi, forming a sbi mRNA-SprD duplex repressing the translation of the mRNA.

sbi protein interferes with the host's innate immune response by binding Factor H, Complement component 3 and IgG.

References

References

  1. (June 2010). "A Staphylococcus aureus small RNA is required for bacterial virulence and regulates the expression of an immune-evasion molecule". PLOS Pathog..
  2. (October 2005). "Small RNA genes expressed from Staphylococcus aureus genomic and pathogenicity islands with specific expression among pathogenic strains". Proc. Natl. Acad. Sci. U.S.A..
  3. (December 2008). "The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b". PLOS Pathog..
  4. (April 1998). "A second IgG-binding protein in Staphylococcus aureus". Microbiology.
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non-coding-rna
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