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Sphinganine C4-monooxygenase

Class of enzymes

Field	Value
Name	Sphinganine C4-monooxygenase
EC_number	1.14.13.169

Sphinganine C4-monooxygenase (, sphingolipid C4-hydroxylase, SUR2 (gene), SBH1 (gene), SBH2 (gene)) is an enzyme with systematic name sphinganine,NADPH:oxygen oxidoreductase (C4-hydroxylating). This enzyme catalyses the following chemical reaction

: sphinganine + NADPH + H+ + O2 \rightleftharpoons phytosphingosine + NADP+ + H2O

Sphinganine C4-monooxygenase is involved in the biosynthesis of sphingolipids in yeast and plants.

References

(November 1997). "Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p". The Journal of Biological Chemistry.
(May 1998). "Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae". The Journal of Biological Chemistry.
(April 2001). "Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana". FEBS Letters.

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ec-1.14.13

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