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SOX2OT

SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, containing at least 5 exons. The SOX2 gene, an important regulator of neurogenesis, lies within one of the introns of SOX2OT. SOX2OT and SOX2DOT (an isoform of SOXOT transcribed from a distal highly conserved element) are expressed in zones of neurogenesis within the brain. It is associated with central nervous system structures in zebrafish and chicken embryonic brains, and is dynamically regulated during embryogenesis. SOX2OT may play a role in vertebrate development.

References

(April 2003). "Mutations in SOX2 cause anophthalmia". Nat. Genet..
(November 2009). "Complex architecture and regulated expression of the Sox2ot locus during vertebrate development". RNA.

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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

non-coding-rna

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