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Sodium orthovanadate

| NFPA-H = 3 | NFPA-F = 0 | NFPA-R = 0

Sodium orthovanadate is the inorganic compound with the chemical formula . It forms a dihydrate . Sodium orthovanadate is a salt of the oxyanion. It is a colorless, water-soluble solid.

Synthesis and structure

Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide: :

The salt features tetrahedral anion centers linked to octahedral cation sites.

Condensation equilibria

Like many oxometalates, orthovanadate is subject to a number of reactions, which have been analyzed by 51V NMR studies. At high pH, ions exist in equilibrium with . At lower pH's, condensation ensues to give various polyoxovanadates. Ultimately, decavanadate is formed.

Biochemistry

Vanadates exhibit a variety of biological activities, in part because they serve as structural mimics of phosphates. It acts as a competitive inhibitor of ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases, and its inhibitory effects can be reversed by dilution or the addition of ethylenediaminetetraacetic acid (EDTA).

Orthovanadate is activated by boiling and adjusting pH to ~10; this depolymerizes decavanadate into the active inhibitor, monovanadate.

References

References

  1. "Archived copy".
  2. {{Greenwood&Earnshaw
  3. (1987). "Die Struktur des Trinatriumvanadattrihydrats". [[Acta Crystallogr.]].
  4. (2007). "Vanadium-51 NMR".
  5. (1983). "Tetrabutylammonium Trihydrogen Decavanadate(V)". [[Inorganic Syntheses.
  6. (2012). "Biochemical and medical importance of vanadium compounds". Acta Biochim. Pol..
  7. (2013). "Comprehensive Inorganic Chemistry II: From Elements to Applications".
  8. Biolabs, New England. "Sodium Orthovanadate (Vanadate) {{!}} NEB".
  9. "Sodium orthovanadate".
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inorganic-compounds sodium-compounds vanadates
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