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Small copper carrier

Small copper carrier or SCC is a small molecule that transports copper in urine. It is excreted in the kidneys in humans or mice where the liver is unable to excrete excess copper in bile. This happens in Wilson's disease where the presence of copper in urine is a diagnostic. It was discovered by Lawrence Wilson Gray and Svetlana Lutsenko. The molecule is 2 kDa. Its exact nature is not yet known but is presumed to be a peptide.

The same peptide also appears in blood and urine of many different mammals. Its copper free molecular weight is 1329.5. In neutral conditions the small copper carrier molecule has a negative charge. Copper is bound to the carrier via oxygen and nitrogen (O or N).

References

References

  1. (13 July 2012). "Copper's previously unknown exit strategy".
  2. Gray, Wilson Lawrence. "Mechanisms of Homeostatic Control of Copper in Tissues". Database for Research Grants.
  3. Gray, Lawrence. (2012). "Urinary Copper Elevation in a Mouse Model of Wilson's Disease Is a Regulated Process to Specifically Decrease the Hepatic Copper Load". PLOS ONE.
  4. (April 2016). "Purification and characterization of a small copper carrier found in mammalian blood plasma and in the urine of mice and dogs with copper overload". FASEB Journal.
  5. (13 July 2020). "Copper Homeostasis in Mammals, with Emphasis on Secretion and Excretion. A Review". International Journal of Molecular Sciences.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

copper-compounds human-proteins metalloproteins
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