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Small-blue-round-cell tumor

Cancerous tumors composed of small cells which stain blue

'''Small blue round cells''' of Ewing Sarcoma

Display of small round blue cells characteristic of desmoplastic small round cell tumour.

In histopathology, a small-blue-round-cell tumour (abbreviated SBRCT), also known as a small-round-blue-cell tumor (SRBCT) or a small-round-cell tumor (SRCT), is any one of a group of malignant neoplasms that have a characteristic appearance under the microscope, i.e. consisting of small round cells that stain blue on routine H&E stained sections.

These tumors are seen more often in children than in adults. They typically represent undifferentiated cells. The predominance of blue staining is because the cells consist predominantly of nucleus, thus they have scant cytoplasm. TOC

Examples

Tumors that belong to this group are:

Desmoplastic small-round-cell tumour
Ewing sarcoma/PNET
Neuroblastoma
Medulloblastoma
Rhabdomyosarcoma
Synovial sarcoma
Carcinoid tumor
Mesothelioma
Small cell lung cancer
Wilms' tumour
Retinoblastoma
Small-cell lymphoma
Hepatoblastoma- only the anaplastic form has round blue cells, the more common fetal and embryonal types do not
Merkel cell carcinoma
Mesenchymal chondrosarcoma

Conditions mimicking SBRCT

Endometrial stromal condensation may mimic a small-blue-round-cell tumour.

References

(July 2008). "Small round blue cell tumours: diagnostic and prognostic usefulness of the expression of B7-H3 surface molecule". Histopathology.
(April 2001). "Development of a molecular taxonomy of small blue round-cell tumors using cDNA microarrays". Nature Genetics.
(February 2007). "Diagnosis of the small round blue cell tumors using multiplex polymerase chain reaction". The Journal of Molecular Diagnostics.
(July 2018). "Ewing sarcoma". Nature Reviews. Disease Primers.
(2018). "Ocular retinoblastoma and neuroblastoma: A cytological impression". J Surg Med.
Gray W, Kocjan G. Diagnostic Cytopathology; . p.307

Info: Wikipedia Source

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