From Surf Wiki (app.surf) — the open knowledge base

Sel-12

The Caenorhabditis elegans sel-12 gene encodes a multi-pass transmembrane domain protein that is similar to human presenilin. sel-12 positively regulates the lin-12 and glp-1 Notch signaling pathways during hermaphrodite gonadal, vulval, and germline development. sel-12 also plays a role in thermotaxis (the nematode worm prefers a certain temperature and moves accordingly).

C. elegans gene abbreviations: sel, Suppressor/Enhancer of Lin-12; lin, cell LINeage defective; glp, Germ Line Proliferation defective.

References

Diane Levitan, Iva Greenwald. (September 1995). "Facilitation of ''lin-12''-mediated signalling by ''sel-12'', a ''Caenorhabditis elegans'' ''S182'' Alzheimer's disease gene". Nature.
Stefan Eimer. (2003). "Analysis and suppression of mutant ''sel-12'' in ''C. elegans''". Ph.D. Thesis, Ludwig-Maximilians Universität, Munich, Germany.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

transmembrane-proteins caenorhabditis-elegans-genes

Want to explore this topic further?

Ask Mako anything about Sel-12 — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report