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Rubulavirinae

Subfamily of viruses

Summary

Subfamily of viruses

  • Orthorubulavirus
  • Pararubulavirus

Rubulavirinae is a subfamily of viruses in the family Paramyxoviridae. Humans, apes, pigs, and dogs serve as natural hosts. There are currently 18 species in the two genera Orthorubulavirus and Pararubulavirus. Members of the subfamily are collectively called rubulaviruses. The subfamily was previously a genus named Rubulavirus but was elevated to subfamily in 2018.

Taxonomy

Subfamily: Rubulavirinae :Genus: Orthorubulavirus :Genus: Pararubulavirus

Structure

Rubulavirions are enveloped, with spherical geometries. The diameter is around 150 nm. Rubulavirus genomes are linear, around 15kb in length. The genome codes for 8 proteins.

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
RubulavirusSphericalEnvelopedLinear

Life cycle

Viral replication is cytoplasmic. Entry into the host cells is achieved after viral attachment to host cells. Replication follows the negative stranded RNA virus replication model. Negative-stranded RNA virus transcription, using polymerase stuttering, through co-transcriptional RNA editing is the method of transcription. The virus exits the host cell by budding. Humans, apes, pigs, and dogs serve as the natural host. Transmission routes are respiratory and saliva.

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
RubulavirusHumans; apes; pigs; dogsNoneGlycoproteinBuddingCytoplasmCytoplasmAerosols; saliva

Clinical symptoms

The virus often infects children and adults who have evaded the virus during childhood. It is associated with mild upper respiratory symptoms and swelling of the salivary glands including the parotid gland. The virus also has the potential to infect testis, CNS and pancreas.

References

References

  1. "Virus Taxonomy: 2019 Release". International Committee on Taxonomy of Viruses.
  2. "Viral Zone". ExPASy.
  3. Cornelissen, Cynthia Nau. (2020). "Lippincott Illustrated Reviews: Microbiology". Wolters Kluwer.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

mononegavirales paramyxoviridae rubulaviruses virus-subfamilies
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