Rube

Arts and entertainment

• Rube Bloom (1902–1976), Jewish American songwriter, pianist, arranger, band leader, vocalist and writer
• Rube Goldberg (1883–1970), American cartoonist, sculptor, author, engineer, and inventor
• Rubin Lacey (1902–1969), American country blues musician, singer and songwriter

Sports

Baseball

• Rube Benton (1890–1937), American Major League Baseball pitcher
• Rube Bressler (1894–1966), American Major League Baseball pitcher
• Rube Currie (1898–1966), American baseball pitcher and manager in the Negro leagues
• Rube DeGroff (1879–1955), American Major League Baseball player
• George "Rube" Deneau (c. 1879–1926), Canadian minor league baseball player, manager and promoter
• Rube Dessau (1883–1952), American Major League Baseball pitcher
• Rube Ehrhardt (1894–1980), American Major League Baseball pitcher
• Rube Ellis (1885–1938), American Major League Baseball player
• Rube Fischer (1916–1997), American Major League Baseball pitcher
• Rube Foster (1879–1930), American baseball player, manager, and pioneer executive in the Negro leagues, member of the Baseball Hall of Fame
• Rube Foster (AL pitcher) (1888–1976), American Major League Baseball player
• Rube Geyer (1884–1962), American Major League Baseball pitcher
• Rube Kisinger (1876–1941), American Major League Baseball pitcher
• Rube Kroh (1886–1944), American Major League Baseball pitcher
• Rube Lutzke (1897–1938), American Major League Baseball player
• Rube Manning (1883–1930), American Major League Baseball pitcher
• Rube Marquard (1886–1980), American Major League Baseball pitcher, member of the Baseball Hall of Fame
• Rube Marshall (1890–1980), American Major League Baseball pitcher
• Rube Melton (1917–1971), American Major League Baseball pitcher
• Rube Novotney (1924–1987), American Major League Baseball player in 1949
• Rube Oldring (1884–1961), American Major League Baseball player
• Rube Parnham (1894–1963), American Major League Baseball pitcher
• Rube Peters (1885–1965), American Major League Baseball pitcher
• Rube Schauer (1891–1957), Major League Baseball pitcher
• Rube Sellers (1881–1952), American Major League Baseball player in 1910
• Rube Vickers (1878–1958), American Major League Baseball pitcher
• Rube Vinson (1879–1951), American Major League Baseball player
• Rube Waddell (1876–1914), American Major League Baseball pitcher
• Rube Walberg (1896–1978), American Major League Baseball pitcher
• Rube Walker (1926–1992), American Major League Baseball catcher and pitching coach
• Rube Ward (1879–1945), American Major League Baseball player in 1902
• Rube Yarrison (1896–1977), American Major League Baseball pitcher

Other

• Rube Barker (1889–1958), American college football player and track athlete in the 1910s
• Rube Bjorkman (born 1929), former collegiate ice hockey head coach
• Rube Brandow (1898–1932), Canadian professional ice hockey player and college coach
• Rube Ferns (1873–1952), American boxer, world welterweight champion in 1900 and 1901
• Rube Lautenschlager (1915–1992), American college and professional basketball player
• Rube Ludwig (c. 1920–1991), Canadian football player
• Rube McCray (1904–1972), head football, men's basketball, and baseball coach and athletic director at the College of William & Mary
• Rube Reiswerg (1912–1998), American professional basketball player
• Rube Ursella (1890–1980), American football player-coach who played during the early years of the National Football League
• Reuben Charles Warnes (1875–1961), British boxer
• Steve Roland Prefontaine (1951-1975), American Long Distance Runner coached by the legendary Bill Bowerman, who called him "Rube" because the small town kid was so direct and upfront with people.

Outlaws

• Rube Burrow (1854–1890), American Old West train robber and outlaw