RPS6KA3

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.

Clinical significance

Mutations in this gene have been associated with Coffin–Lowry syndrome (CLS).

Interactions

RPS6KA3 has been shown to interact with CREB-binding protein, MAPK1 and PEA15.

References

References

1. "Entrez Gene: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3".
2. (February 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". The American Journal of Physiology.
3. (January 2002). "X-linked Coffin-Lowry syndrome (CLS, MIM 303600, RPS6KA3 gene, protein product known under various names: pp90(rsk2), RSK2, ISPK, MAPKAP1)". European Journal of Human Genetics.
4. (October 2001). "Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities". Molecular and Cellular Biology.
5. (November 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". The Journal of Biological Chemistry.
6. (January 1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo". The Journal of Biological Chemistry.
7. (August 2003). "RSK2 activity is regulated by its interaction with PEA-15". The Journal of Biological Chemistry.