RPS6KA1

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions

RPS6KA1 has been shown to interact with:

• IκBα,
• MAPK1,
• TOB1
• TSC2, and
• YWHAB.

References

References

1. (Feb 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". The American Journal of Physiology.
2. "Entrez Gene: RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1".
3. (Jun 1997). "IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase". The EMBO Journal.
4. (Jul 2003). "Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity". Molecular and Cellular Biology.
5. (Apr 2003). "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". The Journal of Biological Chemistry.
6. (Jan 1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo". The Journal of Biological Chemistry.
7. (Feb 2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes to Cells.
8. (Sep 2004). "Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase". Proceedings of the National Academy of Sciences of the United States of America.
9. (Jun 2005). "Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)". The Biochemical Journal.
10. (May 2003). "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity". The Journal of Biological Chemistry.