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Rociverine

Chemical compound

Chemical compound

FieldValue
type
imageRociverine.svg
image_classskin-invert-image
ATC_prefixA03
ATC_suffixAA06
CAS_number53716-44-2
PubChem24892842
DrugBankDB13581
ChemSpiderID28534065
UNIIVI08KS44V0
KEGGD07078
ChEBI135440
ChEMBL4755537
IUPAC_name1-(diethylamino)propan-2-yl (1S,2S)-2-cyclohexyl-2-hydroxycyclohexane-1-carboxylate
C20H=37N=1O=3
SMILESCCN(CC)CC(C)OC(=O)[C@H]1CCCC[C@@]1(C2CCCCC2)O
StdInChIInChI=1S/C20H37NO3/c1-4-21(5-2)15-16(3)24-19(22)18-13-9-10-14-20(18,23)17-11-7-6-8-12-17/h16-18,23H,4-15H2,1-3H3/t16?,18-,20+/m1/s1
StdInChIKeyXPYLKZZOBVLVHB-QDKIRNHSSA-N

| Drugs.com =

| elimination_half-life =

Rociverine is an antispasmodic drug used to treat urinary, gastrointestinal and biliary spasms. It is antimuscarinic drug.

Medical uses

In India, rociverine is used as part of the "Programmed Labour Protocol" to help reduce pain and shorten the duration of labor. However, an analysis of clinical trials provides little evidence supporting its effectiveness in reducing labor duration.

Pharmacology

The (1R,2R) stereoisomer showed 240-fold greater affinity for the muscarinic receptor, but the (1S,2S) compound showed the best selectivity.

References

References

  1. "Rociverine".
  2. (1978). "Rociverine, a new antispasmodic agent with balanced neurotropic and myotropic activity". Arzneimittel-Forschung.
  3. (June 2013). "Antispasmodics for labour". The Cochrane Database of Systematic Reviews.
  4. (July 1995). "Stereoselective inhibition of muscarinic receptor subtypes by the eight stereoisomers related to rociverine". European Journal of Pharmacology.
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tertiary-alcohols diethylamino-compounds carboxylate-esters muscarinic-antagonists cyclohexanes
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