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Ribonucleoside-triphosphate reductase

Field	Value
Name	Ribonucleoside-triphosphate reductase
EC_number	1.17.4.2
CAS_number	9068-66-0
image	4coj.jpg
width	270
caption	Ribonucleoside-triphosphate reductase dimer, Thermotoga maritima

Ribonucleoside-triphosphate reductase (, ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme with systematic name 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase. This enzyme catalyses the following chemical reaction

: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O \rightleftharpoons ribonucleoside triphosphate + thioredoxin

Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.

References

(May 1965). "Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of ''Lactobacillus leichmannii''". The Journal of Biological Chemistry.
(September 1966). "Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii". The Journal of Biological Chemistry.
(1983). "The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation". Struct. Bonding.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-1.17.4

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