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Regulatory region of repBA gene

Field	Value
Name	Pseudoknot of the regulatory region of the repBA gene
image	RF01089.png
width	200
caption	Secondary structure of the pseudoknot of the regulatory region of the repBA gene
Rfam	RF01089
RNA_type	Cis-reg
Tax_domain	Eukaryotes Prokaryotes

In plasmids, the regulatory region of repBA gene forms a pseudoknot. The repA gene, which encodes a protein likely to function as an initiator for replication, and the repB gene are translationally coupled. The leader sequence of the repA mRNA contains two complementary sequences of 8 bases. Base-pairing between these two sequences forms a pseudoknot which is essential for translation. The first of these complementary sequences is found within a stem-loop, which forms a target for RNAI. Binding of RNAI to this stem-loop inhibits pseudoknot formation and translation of RepA.

References

(August 1995). "The replication of an IncL/M plasmid is subject to antisense control". J. Bacteriol..
(March 1999). "Analysis of elements involved in pseudoknot-dependent expression and regulation of the repA gene of an IncL/M plasmid". J. Bacteriol..

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non-coding-rna

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