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Quinolinate synthase

Class of enzymes

Class of enzymes

FieldValue
NameQuinolinate synthase
EC_number2.5.1.72

Quinolinate synthase (, NadA, QS, quinolinate synthetase) is an enzyme with systematic name glycerone phosphate:iminosuccinate alkyltransferase (cyclizing). This enzyme catalyses the following chemical reaction

: glycerone phosphate + iminosuccinate \rightleftharpoons pyridine-2,3-dicarboxylate + 2 H2O + phosphate

This iron-sulfur protein that requires a [4Fe-4S] cluster for activity.

References

References

  1. (July 2005). "Quinolinate synthetase, an iron-sulfur enzyme in NAD biosynthesis". FEBS Letters.
  2. (July 2006). "Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid". Plant Physiology.
  3. (July 2005). "Crystal structure of the NAD biosynthetic enzyme quinolinate synthase". The Journal of Biological Chemistry.
  4. (August 2008). "The [4Fe-4S] cluster of quinolinate synthase from Escherichia coli: investigation of cluster ligands". FEBS Letters.
  5. (August 2008). "Regulation of the activity of Escherichia coli quinolinate synthase by reversible disulfide-bond formation". Biochemistry.
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