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Quasi-irreversible inhibitor

For acetylcholinesterase (AChE), quasi-irreversible inhibitors are those that rapidly phosphorylate AChE. A subsequent internal dealkylation reaction may then occur, which, according to X-ray crystallography data, is suggestive of covalent bond formation. The newly formed OP-enzyme conjugate is as a result permanently deactivated.

Historically, irreversible acetylcholinesterase inhibitors have been used as insecticides and chemical weapons.{{Cite book

References

References

  1. (199). "Crystal structures of aged phosphorylated acetylcholinesterase: nerve agent reaction products at the atomic level". Weizmann Institute of Science.
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