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Pyrrolidine dithiocarbamate

Pyrrolidine dithiocarbamate (PDTC) are a family of closely related drugs used for a metal chelation, induction of G1 phase cell cycle arrest, and preventing induction of nitric oxide synthase.

Pyrrolidine dithiocarbamate binds zinc such that the resulting complex can enter the cell and inhibit viral RNA-dependent RNA polymerase.

Reactions

Pyrrolidine dithiocarbamate, like other dithiocarbamates, forms coordination complexes with a variety of transition metals. One example is .

References

(2004). "PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21^Cip1 expression: Involvement of p38 mitogen activated protein kinase". Journal of Cellular Physiology.
[http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=P8765|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC Ammonium pyrrolidinedithiocarbamate] at [[Sigma-Aldrich]]
(1 April 2007). "PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells". Journal of General Virology.
(1974). "Structural Characterization of Tris(pyrrolidyldithiocarbamato)iron(IV) Perchlorate. Iron Sulfide (FeS₆) Complex of Unusually High Oxidation State". Journal of the American Chemical Society.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

1-pyrrolidinyl-compounds dithiocarbamates

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