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Pyriprole

Chemical compound

Field	Value
Verifiedfields	changed
Watchedfields	changed
verifiedrevid	444077120
image	Pyriprole.svg
image_class	skin-invert-image
width	220
image2	Pyriprole 3D ball.png
image_class2	bg-transparent
alt2	Ball-and-stick model of the pyriprole molecule
tradename	Prac-tic
DailyMedID
pregnancy_AU
routes_of_administration	Topical
class	Ectoparasiticide
ATCvet	yes
ATC_prefix	P53
ATC_suffix	AX26
legal_AU
legal_BR
legal_CA
legal_DE
legal_NZ
legal_UK
legal_US
legal_EU_comment
legal_UN
legal_status
CAS_number_Ref
CAS_number	394730-71-3
PubChem	12056859
DrugBank_Ref
ChemSpiderID_Ref
ChemSpiderID	11677344
UNII_Ref
UNII	69OX73ZVJN
KEGG	C18580
ChEBI	81845
IUPAC_name	1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(difluoromethyl)thio]-5-[(2-pyridinylmethyl)amino]-1H-pyrazole-3-carbonitrile
C	18	H=10	Cl=2	F=5	N=5	S=1
smiles	Clc2cc(C(F)(F)F)cc(Cl)c2-n(nc(C#N)c1SC(F)F)c1NCc3ncccc3
StdInChI_Ref
StdInChI	1S/C18H10Cl2F5N5S/c19-11-5-9(18(23,24)25)6-12(20)14(11)30-16(28-8-10-3-1-2-4-27-10)15(31-17(21)22)13(7-26)29-30/h1-6,17,28H,8H2
StdInChIKey_Ref
StdInChIKey	MWMQNVGAHVXSPE-UHFFFAOYSA-N

| Drugs.com =

Pyriprole, sold under the brand name Prac-tic, is a veterinary medication used for dogs against external parasites such as fleas and ticks.

Pyriprole is a phenylpyrazole derivative similar to fipronil. Although introduced (in the 2000s) and under patent protection it is a "classic" insecticide. It is only approved in the EU and a few other countries for use on dogs. It is not approved for use on cats or livestock. It has not been introduced as an agricultural or hygiene pesticide.

Pyriprole applied as a spot-on is highly effective against fleas and several ticks species. Efficacy against fleas is comparable to that of other modern insecticidal active ingredients such as fipronil, imidacloprid or spinosad. As most flea spot-ons it controls existing flea and tick infestations in about 1 to 2 days, and provides about 4 weeks protection against re-infestations.

Mechanism of action

Pyriprole is an insecticide and acaricide. It inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) resulting in uncontrolled hyperactivity of the central nervous system of fleas and ticks.

Parasites are killed through contact rather than by systemic exposure. Following topical administration pyriprole is rapidly distributed in the hair coat of dogs within one day after application. It can be found in the hair coat throughout the treatment interval. Insecticidal efficacy duration against new infestations with fleas persists for a minimum of four weeks. The substance can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).

References

(18 December 2006). "Prac-tic EPAR".
(20 December 2006). "Prac-tic PI".
(2008). "Small Animal Clinical Pharmacology". Elsevier Health Sciences.
(2008). "Encyclopedia of Parasitology". Springer Rechtswissenschaft.
(2016). "Pyriprole". Springer Berlin Heidelberg.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

insecticides 2-pyridyl-compounds pyrazoles nitriles difluoromethyl-compounds trifluoromethyl-compounds thioethers chlorobenzene-derivatives synthetic-insecticides dog-medications

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