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Pustulosis palmaris et plantaris

Field	Value
name	Pustulosis palmaris et plantaris
synonyms	Pustulosis of palms and soles, Palmoplantar pustulosis, Persistent palmoplantar pustulosis, Pustular psoriasis of the Barber type, and Pustular psoriasis of the extremities
image	Pustular Psoriasis.jpg
caption	Pustulosis palmaris et plantaris
differential	SAPHO syndrome

Pustulosis palmaris et plantaris is a chronic recurrent pustular dermatosis (that is, a pustulosis or pustular psoriasis) localized on the palms and soles only, characterized histologically by intraepidermal pustules filled with neutrophils. It can occur as part of the SAPHO syndrome.

Treatment

Systematic reviews show evidence to support the use of systemic retinoids alone and in combination with photochemotherapy to improve symptoms of chronic palmoplantar pustulosis, with a combination more effective than one alone. There is also evidence to support topical steroids under hydrocolloid occlusion dressings, low dose ciclosporin, tetracyclines, and Grenz-Ray Therapy. There is no evidence to support the use of hydroxyurea in chronic palmoplantar pustulosis.

Treatment with guselkumab, an anti–interleukin 23 monoclonal antibody has shown a decrease in the size of the area affected and severity.

References

(2007). "Dermatology: 2-Volume Set". Mosby.
(2003). "Fitzpatrick's Dermatology in General Medicine". McGraw-Hill.
(2005). "Andrews' Diseases of the Skin: Clinical Dermatology". Saunders.
(November 2009). "SAPHO Syndrome Diagnosis and Treatment: Report of Five Cases and Review of the Literature". The Open Orthopaedics Journal.
(2006-01-25). "Interventions for chronic palmoplantar pustulosis". Cochrane Database of Systematic Reviews.
(July 2019). "Efficacy and Safety of Guselkumab in Japanese Patients With Palmoplantar Pustulosis: A Phase 3 Randomized Clinical Trial". JAMA Dermatology.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

psoriasis recalcitrant-palmoplantar-eruptions

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